Sugi Predict

Sugi Predict / Compounds / SCHEMBL2255352

SCHEMBL2255352

SCHEMBL2255352

CC(Cl)(Cl)C(=O)c1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CES1 P23141 8/20 0.54
▸ SRC P12931 1/20 0.48
▸ CES2 O00748 5/20 0.46
▸ TSHR P16473 4/20 0.46
▸ ALDH1A1 P00352 3/20 0.46
▸ DAO P14920 1/20 0.46
▸ NAPRT Q6XQN6 1/20 0.46
▸ TDP1 Q9NUW8 3/20 0.45
▸ HSD17B10 Q99714 2/20 0.45
▸ MAPK1 P28482 2/20 0.43
▸ TRPA1 O75762 1/20 0.43
▸ GSK3B P49841 1/20 0.43
▸ HIF1A Q16665 1/20 0.43
▸ CYP1A2 P05177 1/20 0.43
▸ POLB P06746 2/20 0.42
▸ CYP3A4 P08684 2/20 0.42
▸ MAPT P10636 2/20 0.42
▸ PARP1 P09874 1/20 0.42
▸ CYP2C19 P33261 1/20 0.42
▸ RECQL P46063 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1445897 0.86 CES1 (0.54) CES1SRCCES2TSHRALDH1A1
SCHEMBL6050014 0.84 CES1 (0.52) CES1SRCCES2TSHRALDH1A1
SCHEMBL11864550 0.84 CES1 (0.52) CES1SRCCES2TSHRALDH1A1
SCHEMBL11308508 0.84 CES1 (0.52) CES1SRCCES2TSHRALDH1A1
SCHEMBL11770873 0.83 CES1 (0.47) CES1SRCCES2TSHRALDH1A1
SCHEMBL27638715 0.82 CES1 (0.50) CES1SRCCES2TSHRALDH1A1
SCHEMBL5182474 0.82 CES1 (0.50) CES1SRCCES2TSHRALDH1A1
SCHEMBL5158726 0.82 CES1 (0.61) CES1SRCCES2TSHRALDH1A1
SCHEMBL226691 0.80 CES1 (0.58) CES1SRCCES2TSHRALDH1A1
SCHEMBL21109870 0.80 CES1 (0.58) CES1SRCCES2TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115436507-A Method for detecting content of 3,4' -dichloropropiophenone 山东京博生物科技有限公司 2022-12-06 — — CN claimed
CN-111454137-B Synthetic method for improving yield of 5-chloro-1-indanone 山东京博生物科技有限公司 2022-09-23 — — CN claimed
CN-214106913-U Preparation facilities is used with mediation to methyl dichloroacetophenone 如东众意化工有限公司 2021-09-03 — — CN claimed
CN-111454137-A Synthetic method for improving yield of 5-chloro-1-indanone 山东京博生物科技有限公司 2020-07-28 — — CN claimed
CN-111205175-A Synthetic method for improving yield of 5-chloro-1-indanone 京博农化科技有限公司 2020-05-29 — — CN claimed
CN-107118103-A A kind of insecticide indoxacarb intermediate and its synthesis technique 连云港市国盛化工有限公司 2017-09-01 — — CN claimed
US-7084281-B2 Synthesis of dihalohydrins and tri- and tetra-substituted olefins BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2006-08-01 — — US claimed
US-20040143125-A1 Synthesis of dihalohydrins and tri- and tetra-substituted olefins BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2004-07-22 — — US claimed
CN-1403434-A Prepn process of 5-chloro-2,3-dihydro-1-indenone WANG MINGCHUN (CN) 2003-03-19 — — CN claimed
US-20230227797-A1 TRANSAMINASE MUTANT AND USE THEREOF ASYMCHEM LABORATORIES (TIANJIN) CO., LTD. (CN) 2023-07-20 — — US disclosed
CN-115436507-A Method for detecting content of 3,4' -dichloropropiophenone 山东京博生物科技有限公司 2022-12-06 — — CN disclosed
CN-111454137-B Synthetic method for improving yield of 5-chloro-1-indanone 山东京博生物科技有限公司 2022-09-23 — — CN disclosed
CN-214106913-U Preparation facilities is used with mediation to methyl dichloroacetophenone 如东众意化工有限公司 2021-09-03 — — CN disclosed
CN-214106913-U Preparation facilities is used with mediation to methyl dichloroacetophenone 如东众意化工有限公司 2021-09-03 — — CN disclosed
US-5096902-A Cerebral antihypoxic action, senile dememtia, Alzheimer's, cognitive functions RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 1992-03-17 — — US disclosed
EP-0411775-A1 Heterocyclic compounds containing nitrogen and sulfur, processes for their preparation and pharmaceutical compositions thereof RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) 1991-02-06 — — EP disclosed
US-4713485-A A, A-DIHALOGENATED KETONES HEATED UNDER PRESSURE WITH AQUEOUS ALKALINE METAL HYDROXIDE AND NON-POLAR HYDROCARBON SOLVENTS SANOFI and Industria Chimica Prodotti FRANCIS S.p.A. (FR) 1987-12-15 — — US disclosed
EP-0144729-A1 11-Substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines, a process for their preparation and their use in medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1985-06-19 — — EP disclosed
US-4426449-A Method for producing vicinal dihalogenated products CETUS CORPORATION (US) 1984-01-17 — — US disclosed
EP-0082006-A2 Method for producing vicinal dihalogenated products and uses thereof, and process for preparing epoxides using the same CETUS CORPORATION (US) 1983-06-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040143125-A1 Synthesis of dihalohydrins and tri- and tetra-substituted olefins TALDO1, HDHD5, TKT CES1 318/4885SRC 3482/4885CES2 324/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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