Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Dl-Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | TSHR | P16473 | 2/20 | 0.78 |
| ▸ | BLM | P54132 | 2/20 | 0.78 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | MPO | P05164 | 1/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.78 |
| ▸ | MC4R | P32245 | 2/20 | 0.61 |
| ▸ | MC5R | P33032 | 1/20 | 0.61 |
| ▸ | MC3R | P41968 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL1781955 | 1.00 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL30058301 | 1.00 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL3515219 | 1.00 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL26981429 | 1.00 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27153934 | 1.00 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27705509 | 0.96 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL21219049 | 0.95 | KMT2A (0.71) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6030686 | 0.94 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL14719809 | 0.92 | KDM4E (0.67) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27584251 | 0.92 | KDM4E (0.67) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018132876-A1 | NOVEL GLYCINE TRANSPORT INHIBITORS FOR THE TREATMENT OF PAIN | THE UNIVERSITY OF SYDNEY (AU) | 2018-07-26 | — | — | WO | claimed |
| EP-2502933-B1 | METHOD FOR PREPARING GINTONIN, WHICH IS A NOVEL GLYCOLIPOPROTEIN FROM PANAX GINSENG, AND GINTONIN, WHICH IS A NOVEL GLYCOLIPOPROTEIN, PREPARED BY THE METHOD | UNIV KONKUK IND COOP CORP (KR) | 2014-07-02 | — | — | EP | claimed |
| US-20120282232-A1 | Nutrient Hydration Bar | TOBIN JOHN GEORGE (US) | 2012-11-08 | — | — | US | claimed |
| EP-2502933-A2 | METHOD FOR PREPARING GINTONIN, WHICH IS A NOVEL GLYCOLIPOPROTEIN FROM PANAX GINSENG, AND GINTONIN, WHICH IS A NOVEL GLYCOLIPOPROTEIN, PREPARED BY THE METHOD | Konkuk University Industrial Cooperation Corp. (KR) | 2012-09-26 | — | — | EP | claimed |
| EP-2361602-A2 | A hair building solid agent | Pangaea Laboratories Limited (GB) | 2011-08-31 | — | — | EP | claimed |
| US-20110195039-A1 | HAIR BUILDING SOLID AGENT | PANGAEA LABORATORIES LTD. (GB) | 2011-08-11 | — | — | US | claimed |
| EP-1543032-B1 | METHOD FOR THE RATIONAL MUTAGENESIS OF A/BETA T CELL RECEPTORS AND CORRESPONDINGLY MUTATED MDM2 PROTEIN-SPECIFIC A/BETA T-CELL RECEPTORS | UNIV MAINZ JOHANNES GUTENBERG (DE) | 2009-01-07 | — | — | EP | claimed |
| CN-1456046-A | Selective breeding technology for high-quality glutinous protein corn hybrid | HUANG BINGSHENG (CN) | 2003-11-19 | — | — | CN | claimed |
| CN-1125343-C | Chromatographic device and method using polyanion neutralization polycation action | ABBOTT LAB (US) | 2003-10-22 | — | — | CN | claimed |
| CN-111533789-B | Tryptophan and lysine chain-crossing interaction beta-hairpin antibacterial peptide and preparation method thereof | 东北农业大学 | 2021-12-14 | — | — | CN | disclosed |
| CN-111423492-B | Beta-hairpin antibacterial peptide containing D-type proline and glycine corner and preparation method thereof | 东北农业大学 | 2021-12-14 | — | — | CN | disclosed |
| CN-111533789-A | Tryptophan and lysine chain-crossing interaction beta-hairpin antibacterial peptide and preparation method thereof | 东北农业大学 | 2020-08-14 | — | — | CN | disclosed |
| CN-111423492-A | β hairpin antibacterial peptide containing D-type proline and glycine corner and preparation method thereof | 东北农业大学 | 2020-07-17 | — | — | CN | disclosed |
| CN-110331154-A | Target the Chimeric antigen receptor of B- cell maturation antigen | 美国卫生和人力服务部 | 2019-10-15 | — | — | CN | disclosed |
| EP-2361602-A2 | A hair building solid agent | Pangaea Laboratories Limited (GB) | 2011-08-31 | — | — | EP | disclosed |
| US-20110195039-A1 | HAIR BUILDING SOLID AGENT | PANGAEA LABORATORIES LTD. (GB) | 2011-08-11 | — | — | US | disclosed |
| WO-2009120665-A2 | COMPOSITIONS INCLUDING DE-OILED DISTILLERS DRIED GRAINS WITH SOLUBLES AND METHODS OF USING THE SAME | VERASUN ENERGY CORPORATION (US) | 2009-10-01 | — | — | WO | disclosed |
| US-6169232-B1 | AMINO ACID SEQUENCE OF PROTEINS; FOR TRANSGENIC CORN SEEDS | DOW AGROSCIENCES LLC | 2001-01-02 | — | — | US | disclosed |
| CN-1191018-A | Modified avidin and streptavidin and uses thereof | YEDA RES & DEV (NL) | 1998-08-19 | — | — | CN | disclosed |
| CN-1039843-A | The method for making of people's epithelial cell growth factor | NIPPON SHINYAKU CO LTD (JP) | 1990-02-21 | — | — | CN | disclosed |