Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | LMNA | P02545 | 2/20 | 0.78 |
| ▸ | TSHR | P16473 | 2/20 | 0.78 |
| ▸ | BLM | P54132 | 2/20 | 0.78 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | MPO | P05164 | 1/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.78 |
| ▸ | MC4R | P32245 | 2/20 | 0.61 |
| ▸ | MC5R | P33032 | 1/20 | 0.61 |
| ▸ | MC3R | P41968 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | APAF1 | O14727 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL1781955 | 1.00 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL2255452 | 1.00 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL30058301 | 1.00 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL26981429 | 1.00 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27153934 | 1.00 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27705509 | 0.96 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL21219049 | 0.95 | KMT2A (0.71) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL6030686 | 0.94 | KDM4E (0.70) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL14719809 | 0.92 | KDM4E (0.67) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27584251 | 0.92 | KDM4E (0.67) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4301790-A1 | SUNSCREENS DERIVED FROM KYNURENINES AND OTHER UV-ABSORBING OXIDIZED AMINO ACIDS BOUND TO PEPTIDES OR POLYMERS | The Trustees Of Princeton University (US) | 2024-01-10 | — | — | EP | disclosed |
| CN-116444603-A | Tryptophan-containing antibacterial peptide and synthesis method and application thereof | 江苏大学 | 2023-07-18 | — | — | CN | disclosed |
| CN-116444603-A | Tryptophan-containing antibacterial peptide and synthesis method and application thereof | 江苏大学 | 2023-07-18 | — | — | CN | disclosed |
| US-20100311821-A1 | Synthetic vector | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2010-12-09 | — | — | US | disclosed |
| WO-1995026733-A1 | OLIGONUCLEOSIDE CLEAVAGE COMPOUNDS AND THERAPIES | GENTA INCORPORATED (US) | 1995-10-12 | — | — | WO | disclosed |