Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | MPO | P05164 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | MC4R | P32245 | 2/20 | 0.56 |
| ▸ | MC5R | P33032 | 1/20 | 0.56 |
| ▸ | MC3R | P41968 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL1781955 | 0.94 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27153934 | 0.94 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL3515219 | 0.94 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL26981429 | 0.94 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL2255452 | 0.94 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL30058301 | 0.94 | KDM4E (0.78) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27705509 | 0.91 | KDM4E (0.80) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL21219049 | 0.90 | KMT2A (0.71) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28340345 | 0.90 | KMT2A (0.56) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL8406412 | 0.90 | KDM4E (0.86) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7112442-B2 | Peptides for gene delivery | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-09-26 | — | — | US | disclosed |
| US-20030170894-A1 | Peptides for gene delivery | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2003-09-11 | — | — | US | disclosed |
| US-6387700-B1 | BINDING TRYPTOPHAN-CONTAINING PEPTIDE TO NUCLEIC ACID TO MAKE COMPLEX, THEN INTRODUCING COMPLEX TO CELL SO THAT IT IS DELIVERED ACROSS THE CELL MEMBRANE | THE REAGENTS OF THE UNIVERSITY OF MICHIGAN | 2002-05-14 | — | — | US | disclosed |
| WO-1998019711-A9 | PEPTIDES FOR GENE DELIVERY | — | 1998-09-03 | — | — | WO | disclosed |
| WO-1998019711-A1 | PEPTIDES FOR GENE DELIVERY | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1998-05-14 | — | — | WO | disclosed |