Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17512605 | 0.86 | MAPK1 (0.53) | ALDH1A1MAPTHTTCYP2C19KMT2A | |
| SCHEMBL23147201 | 0.83 | MAPT (0.45) | ALDH1A1MAPTHTTPKMKMT2A | |
| SCHEMBL28661618 | 0.81 | PKM (0.47) | ALDH1A1MAPTHTTCYP2C19PKM | |
| SCHEMBL17055210 | 0.80 | CYP2C19 (0.47) | ALDH1A1MAPTCYP2C19KMT2ANPC1 | |
| SCHEMBL16522671 | 0.77 | KMT2A (0.47) | ALDH1A1MAPTCYP2C19KMT2ANPC1 | |
| SCHEMBL7499244 | 0.77 | CYP2C19 (0.53) | ALDH1A1MAPTHTTCYP2C19PKM | |
| SCHEMBL28692379 | 0.76 | ALDH1A1 (0.51) | ALDH1A1MAPTHTTCYP2C19KMT2A | |
| SCHEMBL17467144 | 0.75 | CYP2C19 (0.42) | ALDH1A1MAPTHTTCYP2C19PKM | |
| SCHEMBL17467142 | 0.75 | CYP2C19 (0.42) | ALDH1A1MAPTHTTCYP2C19PKM | |
| SCHEMBL29081418 | 0.75 | HTT (0.49) | ALDH1A1MAPTHTTCYP2C19PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113710664-B | JAK1 selective kinase inhibitors | 迪哲(江苏)医药股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| EP-3956322-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2022-02-23 | — | — | EP | disclosed |
| CN-113710664-A | JAK1 selective kinase inhibitors | 迪哲(江苏)医药股份有限公司 | 2021-11-26 | — | — | CN | disclosed |
| WO-2020211839-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-10-22 | — | — | WO | disclosed |