Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 7/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22557381 | 0.89 | FAAH (0.49) | FAAHUSP30CA12CA1CA2 | |
| SCHEMBL22557064 | 0.88 | FAAH (0.48) | FAAHUSP30CA12CA1CA2 | |
| SCHEMBL22557053 | 0.86 | FAAH (0.47) | FAAHUSP30CA12CA1CA2 | |
| SCHEMBL22557556 | 0.85 | FAAH (0.46) | FAAHUSP30CA12CA1CA2 | |
| SCHEMBL25213012 | 0.82 | FAAH (0.45) | FAAHUSP30CA12CA1CA2 | |
| SCHEMBL25214308 | 0.82 | FAAH (0.45) | FAAHUSP30CA12CA1CA2 | |
| SCHEMBL22557010 | 0.82 | FAAH (0.45) | FAAHUSP30CA12CA1CA2 | |
| SCHEMBL22557644 | 0.81 | FAAH (0.47) | FAAHUSP30CA12CA1CA2 | |
| SCHEMBL25215099 | 0.80 | FAAH (0.43) | FAAHUSP30CA12CA1CA2 | |
| SCHEMBL22585725 | 0.79 | USP30 (0.57) | FAAHUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020212350-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-10-22 | — | — | WO | claimed |
| WO-2020212350-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-10-22 | — | — | WO | disclosed |
| WO-2020212350-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-10-22 | — | — | WO | disclosed |