Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CTSC | P53634 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22557481 | 0.89 | FAAH (0.51) | FAAHUSP30HDAC1HDAC6LRRK2 | |
| SCHEMBL22557556 | 0.88 | FAAH (0.46) | FAAHUSP30HDAC1HDAC6LRRK2 | |
| SCHEMBL22557053 | 0.88 | FAAH (0.47) | FAAHUSP30HDAC1HDAC6LRRK2 | |
| SCHEMBL22557005 | 0.88 | FAAH (0.45) | FAAHUSP30HDAC1HDAC6LRRK2 | |
| SCHEMBL22557010 | 0.87 | FAAH (0.45) | FAAHUSP30HDAC1HDAC6LRRK2 | |
| SCHEMBL24073259 | 0.86 | HDAC1 (0.51) | USP30HDAC1HDAC6 | |
| SCHEMBL24072853 | 0.86 | HDAC1 (0.51) | USP30HDAC1HDAC6 | |
| SCHEMBL30370217 | 0.86 | HDAC1 (0.51) | USP30HDAC1HDAC6 | |
| SCHEMBL24072855 | 0.86 | HDAC1 (0.51) | USP30HDAC1HDAC6 | |
| SCHEMBL30370111 | 0.86 | HDAC1 (0.51) | USP30HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020212350-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-10-22 | — | — | WO | claimed |
| WO-2020212350-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-10-22 | — | — | WO | disclosed |
| WO-2020212350-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-10-22 | — | — | WO | disclosed |