Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.51 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22557064 | 0.89 | FAAH (0.48) | FAAHUSP30SMYD3LRRK2HDAC1 | |
| SCHEMBL22585734 | 0.88 | FAAH (0.43) | FAAHUSP30SMYD3HCRTR2LRRK2 | |
| SCHEMBL22556938 | 0.87 | FAAH (0.49) | FAAHUSP30LRRK2HDAC1HDAC6 | |
| SCHEMBL22556910 | 0.87 | FAAH (0.51) | FAAHUSP30HDAC1HDAC6CA12 | |
| SCHEMBL22557381 | 0.87 | FAAH (0.49) | FAAHUSP30LRRK2HDAC1HDAC6 | |
| SCHEMBL25218982 | 0.87 | FAAH (0.49) | FAAHUSP30HDAC1HDAC6CA12 | |
| SCHEMBL22557452 | 0.87 | FAAH (0.49) | FAAHUSP30LRRK2HDAC1HDAC6 | |
| SCHEMBL23069418 | 0.85 | USP30 (0.42) | FAAHUSP30SMYD3HCRTR2LRRK2 | |
| SCHEMBL25215194 | 0.85 | FAAH (0.49) | FAAHUSP30HDAC1HDAC6CA12 | |
| SCHEMBL29269018 | 0.85 | FAAH (0.49) | FAAHUSP30HDAC1HDAC6CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020212350-A1 | SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS USP30 INHIBITORS | MISSION THERAPEUTICS LIMITED (GB) | 2020-10-22 | — | — | WO | disclosed |