Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22557500 | 0.82 | KDM4E (0.44) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL249721 | 0.82 | KDM4E (0.44) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL9018039 | 0.81 | KDM4E (0.44) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL22557367 | 0.80 | KDM4E (0.41) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL27589085 | 0.80 | KDM4E (0.41) | KDM4EPOLBRAB9AMEN1KMT2A | |
| SCHEMBL27816536 | 0.78 | PREP (0.42) | KDM4EALDH1A1HSD17B10NNMTMKNK1 | |
| SCHEMBL4948493 | 0.78 | KDM4E (0.60) | KDM4ERAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL3362074 | 0.77 | ACACB (0.39) | KDM4EPOLBRAB9A | |
| SCHEMBL23320591 | 0.77 | KDM4E (0.58) | KDM4ERAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL2414089 | 0.77 | KDM4E (0.46) | KDM4ERAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956322-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020211839-A1 | JAK1 SELECTIVE KINASE INHIBITOR | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-10-22 | — | — | WO | disclosed |
| CN-104045552-B | Medicinal compound as neuroprotective agent | 江苏先声药业有限公司 | 2019-06-11 | — | — | CN | disclosed |
| CN-105073738-A | Quinoline and quinazoline amides as modulators of sodium channels | VERTEX PHARMA | 2015-11-18 | — | — | CN | disclosed |
| CN-104968647-A | Amides as modulators of sodium channels | VERTEX PHARMA | 2015-10-07 | — | — | CN | disclosed |
| CN-104718206-A | Azaindole carboxylic acid amides and azaindole thiocarboxylic acid amides for use as insecticides and acaricides | BAYER CROPSCIENCE AG | 2015-06-17 | — | — | CN | disclosed |
| CN-101967146-B | Aryl or heteroaryl fused imidazole compounds as anti-inflammatory and analgesic agents | RAQUALIA PHARMA INC | 2015-04-08 | — | — | CN | disclosed |
| CN-102827082-B | Thienopyrazole derivative having PDE7 inhibitory activity | DAIICHI SANKYO CO LTD | 2015-01-07 | — | — | CN | disclosed |
| CN-104045552-A | Medicinal compound as neuroprotective agent | SHANGHAI SIMCERE PHARMACEUTICAL RES CO LTD | 2014-09-17 | — | — | CN | disclosed |
| CN-103221408-A | Triazine-oxadiazole compounds | NOVARTIS AG | 2013-07-24 | — | — | CN | disclosed |
| CN-101821236-B | Five-membered heterocyclic compound | RES FOUND ITSUU LAB | 2013-05-08 | — | — | CN | disclosed |
| CN-101967146-A | Ep4 receptor inhibitors to treat rheumatoid arthritis | PRIZER JAPAN INC | 2011-02-09 | — | — | CN | disclosed |
| CN-101855199-A | Tricyclic amide compound | RES FOUND ITSUU LAB | 2010-10-06 | — | — | CN | disclosed |
| CN-101821236-A | Five-membered heterocyclic compound | RES FOUND ITSUU LAB | 2010-09-01 | — | — | CN | disclosed |
| CN-100347172-C | Azaindole-derivatives as factor Xa inhibitors | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-11-07 | — | — | CN | disclosed |
| CN-1976938-A | Thienopyrazole derivatives having PDE7 inhibitory activity | ASUBIO PHARMA CO LTD (JP) | 2007-06-06 | — | — | CN | disclosed |
| CN-1791601-A | azaindole derivatives as factor Xa inhibitors | SANOFI AVENTIS DEUTSCHLAND (DE) | 2006-06-21 | — | — | CN | disclosed |
| CN-1476448-A | Aryl or heteroaryl fused imidazole compounds as anti-inflammatory and analgesic agents | ������ҩ������˾ | 2004-02-18 | — | — | CN | disclosed |