Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.49 |
| ▸ | BMPR1B | O00238 | 9/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 9/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 9/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 9/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22585726 | 1.00 | PIK3C3 (0.49) | PIK3C3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL29041999 | 0.92 | PIK3C3 (0.56) | PIK3C3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL30508263 | 0.92 | PIK3C3 (0.56) | PIK3C3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL30964448 | 0.85 | SMYD3 (0.55) | PIK3C3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL3059096 | 0.85 | SMYD3 (0.55) | PIK3C3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL22585959 | 0.83 | OPRK1 (0.44) | HPGDSOPRK1CNR2PLATHDAC3 | |
| SCHEMBL22558810 | 0.83 | CNR2 (0.55) | PIK3C3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL30508193 | 0.81 | BMPR1B (0.44) | PIK3C3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL20995120 | 0.81 | BMPR1B (0.62) | PIK3C3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL20995270 | 0.81 | BMPR1B (0.62) | PIK3C3BMPR1BBMPR1ATGFBR1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3956330-A1 | SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF | The Johns Hopkins University (US) | 2022-02-23 | — | — | EP | disclosed |
| WO-2020215094-A1 | SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-10-22 | — | — | WO | disclosed |
| WO-2020215094-A1 | SUBSTITUTED 2-AMINO-PYRAZOLYL-[1,2,4]TRIAZOLO[1,5A] PYRIDINE DERIVATIVES AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-10-22 | — | — | WO | disclosed |