Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412304 | 0.83 | KDM4E (0.57) | KDM4ESLC6A4AKR1C3AKR1C2SLC6A2 | |
| SCHEMBL412297 | 0.83 | KDM4E (0.57) | KDM4ESLC6A4AKR1C3AKR1C2SLC6A2 | |
| SCHEMBL12101192 | 0.83 | KDM4E (0.57) | KDM4ESLC6A4AKR1C3AKR1C2SLC6A2 | |
| SCHEMBL441857 | 0.83 | KDM4E (0.57) | KDM4ESLC6A4AKR1C3AKR1C2SLC6A2 | |
| SCHEMBL5140474 | 0.83 | KDM4E (0.57) | KDM4ESLC6A4AKR1C3AKR1C2SLC6A2 | |
| SCHEMBL6839350 | 0.83 | KDM4E (0.46) | KDM4ECYP3A4CYP2D6 | |
| SCHEMBL13264873 | 0.81 | SLC6A4 (0.48) | KDM4ESLC6A4AKR1C3AKR1C2ACACB | |
| Hydrochloric Acid SCHEMBL444253 | 0.81 | ALDH1A1 (0.59) | KDM4ESLC6A4AKR1C3AKR1C2SLC6A2 | |
| SCHEMBL16788780 | 0.81 | SLC6A4 (0.41) | KDM4ESLC6A4AKR1C3AKR1C2ACACB | |
| SCHEMBL7557160 | 0.80 | SLC6A4 (0.53) | KDM4ESLC6A4AKR1C3AKR1C2ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10807962-B2 | Process for the synthesis of firocoxib | COSMA S.P.A. (IT) | 2020-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10807962-B2 | Process for the synthesis of firocoxib | RIOX2, PPOX, CYP4X1 | KDM4E 391/4885SLC6A4 4161/4885AKR1C3 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.