Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.72 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.67 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.65 |
| ▸ | SCD | O00767 | 1/20 | 0.65 |
| ▸ | ACP1 | P24666 | 1/20 | 0.62 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.56 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.53 |
| ▸ | IKBKB | O14920 | 2/20 | 0.51 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 1/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.49 |
| ▸ | WNT3A | P56704 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10252594 | 0.84 | KDR (1.00) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL5840422 | 0.84 | KDR (0.72) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL6281775 | 0.81 | CNR1 (0.82) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL69753 | 0.81 | CCNE1 (0.74) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL17014785 | 0.81 | KDR (0.68) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL27692131 | 0.81 | CSNK2A2 (0.67) | KDRIKBKB | |
| SCHEMBL27224641 | 0.80 | GSTO1 (1.00) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL25682655 | 0.80 | KDR (0.67) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL16562035 | 0.79 | SCD (1.00) | KDRGSTO1CCNE1CDK2CDK5 | |
| SCHEMBL19974173 | 0.79 | GSTO1 (0.72) | KDRGSTO1CCNE1CDK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998990-B2 | 5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2011-08-16 | — | — | US | disclosed |
| CN-101448801-B | 5-Phenyl-thiazol-2-yl-urea derivatives and their use as PI3 kinase inhibitors | NOVARTIS AG | 2011-06-15 | — | — | CN | disclosed |
| CN-101448801-B | 5-Phenyl-thiazol-2-yl-urea derivatives and their use as PI3 kinase inhibitors | NOVARTIS AG | 2011-06-15 | — | — | CN | disclosed |
| CN-101448801-A | 5-Phenyl-thiazol-2-yl-urea derivatives and their use as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2009-06-03 | — | — | CN | disclosed |
| CN-101448801-A | 5-Phenyl-thiazol-2-yl-urea derivatives and their use as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2009-06-03 | — | — | CN | disclosed |