SCHEMBL22562239

SCHEMBL22562239

N#Cc1cc(C#N)cc(-c2ccc3c(c2)c2cc(-c4cc(C#N)cc(C#N)c4)ccc2n3-c2cc(-c3cccc(-c4ccccc4)n3)c(-n3c4ccc(-c5cc(C#N)cc(C#N)c5)cc4c4cc(-c5cc(C#N)cc(C#N)c5)ccc43)cc2C#N)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A3 P47895 2/20 0.39
GABRA1 P14867 1/20 0.36
GABRG2 P18507 1/20 0.36
GABRB3 P28472 1/20 0.36
GABRA5 P31644 1/20 0.36
GABRA3 P34903 1/20 0.36
MYC P01106 1/20 0.35
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
ADORA2A P29274 1/20 0.34
TGFBR1 P36897 1/20 0.34
MEN1 O00255 4/20 0.33
KMT2A Q03164 4/20 0.33
RAB9A P51151 1/20 0.33
ABCB1 P08183 1/20 0.33
ABCG2 Q9UNQ0 1/20 0.33
AKT1 P31749 1/20 0.33
CYP1A2 P05177 4/20 0.32
CYP3A4 P08684 3/20 0.32
ALDH1A1 P00352 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562240 0.98 ALDH1A3 (0.38) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562462 0.92 TGFBR1 (0.38) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562554 0.92 ALDH1A3 (0.38) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562202 0.92 ALDH1A3 (0.38) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562241 0.92 ALDH1A3 (0.39) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL19908972 0.91 MYC (0.40) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562347 0.90 CYP11B1 (0.36) ALDH1A3GABRG2GABRB3GABRA5GABRA3
SCHEMBL22562212 0.89 CYP11B1 (0.36) GABRG2GABRB3GABRA5GABRA3CYP11B1
SCHEMBL22562348 0.89 CLK4 (0.38) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL21278886 0.89 MEN1 (0.38) ALDH1A3GABRA1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed