SCHEMBL22562260

SCHEMBL22562260

N#Cc1cc(C#N)cc(-c2ccc3c(c2)c2ccccc2n3-c2cc(C#N)cc(-n3c4ccccc4c4cc(-c5cc(C#N)cc(C#N)c5)ccc43)c2-c2cccc(-c3ccccc3)n2)c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A3 P47895 2/20 0.40
GABRA1 P14867 2/20 0.36
GABRG2 P18507 2/20 0.36
GABRB3 P28472 2/20 0.36
GABRA5 P31644 2/20 0.36
GABRA3 P34903 2/20 0.36
MYC P01106 1/20 0.35
ADORA2A P29274 1/20 0.34
MEN1 O00255 4/20 0.34
KMT2A Q03164 4/20 0.34
RAB9A P51151 1/20 0.34
PTGER4 P35408 1/20 0.34
ABCB1 P08183 1/20 0.33
ABCG2 Q9UNQ0 1/20 0.33
CYP1A2 P05177 6/20 0.33
CYP3A4 P08684 5/20 0.33
ALDH1A1 P00352 4/20 0.33
LMNA P02545 4/20 0.33
CYP2D6 P10635 4/20 0.33
TSHR P16473 4/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562209 0.97 ALDH1A3 (0.42) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562261 0.96 ALDH1A3 (0.45) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562439 0.94 MYC (0.40) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562258 0.94 ALDH1A3 (0.40) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562438 0.92 ALDH1A3 (0.47) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562484 0.91 CTSS (0.36) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL21546627 0.90 ALDH1A3 (0.43) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL19909101 0.90 MYC (0.41) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562259 0.90 ALDH1A3 (0.42) ALDH1A3GABRA1GABRG2GABRB3GABRA5
SCHEMBL22562271 0.90 MYC (0.42) ALDH1A3GABRA1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed