SCHEMBL22562277

SCHEMBL22562277

N#Cc1cc(C#N)cc(-c2ccc3c4ccccc4n(-c4cc(-c5cccc(-c6ccccc6)n5)cc(-n5c6ccccc6c6ccc(-c7cc(C#N)cc(C#N)c7)cc65)c4C(F)(F)F)c3c2)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A3 P47895 1/20 0.38
PDK2 Q15119 1/20 0.35
ADORA2A P29274 2/20 0.34
GABRG2 P18507 2/20 0.34
GABRB3 P28472 2/20 0.34
GABRA5 P31644 2/20 0.34
GABRA3 P34903 2/20 0.34
GABRA1 P14867 1/20 0.34
CTSS P25774 1/20 0.34
PGR P06401 1/20 0.34
ABCB1 P08183 1/20 0.33
ABCG2 Q9UNQ0 1/20 0.33
PDPK1 O15530 1/20 0.33
MYC P01106 1/20 0.33
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.32
IRAK4 Q9NWZ3 1/20 0.32
PTPN5 P54829 1/20 0.32
SYK P43405 1/20 0.32
ENPP1 P22413 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562255 0.97 ALDH1A3 (0.39) ALDH1A3PDK2ADORA2AGABRG2GABRB3
SCHEMBL22562254 0.94 ALDH1A3 (0.38) ALDH1A3PDK2ADORA2AGABRG2GABRB3
SCHEMBL22761025 0.94 ALDH1A3 (0.42) ALDH1A3PDK2ADORA2AGABRG2GABRB3
SCHEMBL22562273 0.94 MYC (0.40) ALDH1A3PDK2GABRG2GABRB3GABRA5
SCHEMBL22562275 0.91 MYC (0.42) ALDH1A3PDK2GABRG2GABRB3GABRA5
SCHEMBL21547044 0.91 ALDH1A3 (0.44) ALDH1A3PDK2ADORA2AGABRG2GABRB3
SCHEMBL22562326 0.91 ALDH1A3 (0.39) ALDH1A3PDK2ADORA2AGABRG2GABRB3
SCHEMBL22562385 0.89 ALDH1A3 (0.39) ALDH1A3ADORA2AGABRG2GABRB3GABRA5
SCHEMBL21546526 0.89 PTPN5 (0.41) ALDH1A3PDK2ADORA2AGABRG2GABRB3
SCHEMBL22562274 0.88 MYC (0.40) ALDH1A3PDK2GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed