SCHEMBL22562402

SCHEMBL22562402

Cc1ccc(-c2ccc3c4ccc(-c5ccc(C)cc5C)cc4n(-c4cc(C(F)(F)F)cc(-n5c6cc(-c7ccc(C)cc7C)ccc6c6ccc(-c7ccc(C)cc7C)cc65)c4-c4cccc(-c5ccccc5)n4)c3c2)c(C)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.35
PDK2 Q15119 4/20 0.34
ENPP1 P22413 1/20 0.33
GSK3B P49841 2/20 0.32
SLC1A3 P43003 1/20 0.32
SLC1A2 P43004 1/20 0.32
SLC1A1 P43005 1/20 0.32
HSD11B1 P28845 1/20 0.31
MAT2A P31153 2/20 0.31
DHODH Q02127 1/20 0.31
TOP1 P11387 1/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
METAP2 P50579 1/20 0.31
RAB9A P51151 1/20 0.31
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
RECQL P46063 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22562403 0.92 ENPP1 (0.35) MAPTPDK2ENPP1GSK3BSLC1A3
SCHEMBL22562229 0.92 ENPP1 (0.35) MAPTPDK2ENPP1GSK3BSLC1A3
SCHEMBL22562345 0.91 PDK2 (0.39) MAPTPDK2ENPP1GSK3BMAT2A
SCHEMBL22562230 0.90 RAB9A (0.36) MAPTENPP1GSK3BMAT2ADHODH
SCHEMBL22562472 0.89 GSK3B (0.35) MAPTGSK3BMAT2ADHODHMEN1
SCHEMBL22562407 0.89 PDK2 (0.37) PDK2ENPP1GSK3BMETAP2
SCHEMBL22562231 0.87 KIF11 (0.36) MAPTENPP1GSK3BMAT2AMEN1
SCHEMBL22562473 0.86 GSK3B (0.33) MAPTENPP1GSK3BMAT2ADHODH
SCHEMBL22562299 0.86 MAPT (0.36) MAPTPDK2ENPP1HSD11B1DHODH
SCHEMBL22562227 0.86 MAPT (0.36) MAPTPDK2ENPP1DHODHMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3418278-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2020-10-21 EP disclosed