SCHEMBL22562944

SCHEMBL22562944

CCOC(=O)c1ccc(O[C@@H]2CCCCCC(C)CC2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN1A P35498 1/20 0.56
SCN2A Q99250 1/20 0.56
SCN3A Q9NY46 1/20 0.56
EPHX2 P34913 5/20 0.51
MAOA P21397 2/20 0.50
MAOB P27338 1/20 0.50
PARP10 Q53GL7 1/20 0.48
LMNA P02545 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
ALOX15 P16050 1/20 0.47
RAB9A P51151 3/20 0.47
NPC1 O15118 2/20 0.47
ALDH1A1 P00352 3/20 0.46
POLB P06746 1/20 0.46
HTT P42858 1/20 0.46
MAPT P10636 2/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3910337 0.93 SCN1A (0.58) SCN1ASCN2ASCN3AEPHX2MAOA
SCHEMBL22564754 0.91 SCN1A (0.52) SCN1ASCN2ASCN3AEPHX2MAOA
SCHEMBL11758763 0.89 PARP10 (0.59) SCN1ASCN2ASCN3AEPHX2MAOA
SCHEMBL11756971 0.87 LMNA (0.61) SCN1ASCN2ASCN3AEPHX2MAOA
SCHEMBL6539173 0.84 SCN1A (0.55) SCN1ASCN2ASCN3AEPHX2MAOA
SCHEMBL22563077 0.83 EPHX2 (0.63) SCN1ASCN2ASCN3AEPHX2PARP10
SCHEMBL23515189 0.82 LMNA (0.54) SCN1ASCN2ASCN3AEPHX2MAOA
SCHEMBL6134218 0.81 ALDH1A1 (0.60) SCN1ASCN2ASCN3AALDH1A1POLB
SCHEMBL237386 0.81 LMNA (0.57) SCN1ASCN2ASCN3AEPHX2MAOA
SCHEMBL1169295 0.80 EPHX2 (0.54) SCN1ASCN2ASCN3AEPHX2MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3725777-A1 BENZO- AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS Rottapharm Biotech S.r.l. (IT) 2020-10-21 EP disclosed