Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 9/20 | 0.49 |
| ▸ | MET | P08581 | 7/20 | 0.48 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | TEK | Q02763 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29693548 | 0.94 | PDGFRB (0.62) | PDGFRACSF1RPDGFRBKITRET | |
| SCHEMBL372681 | 0.94 | PDGFRB (0.62) | PDGFRACSF1RPDGFRBKITRET | |
| SCHEMBL31324666 | 0.94 | PDGFRB (0.62) | PDGFRACSF1RPDGFRBKITRET | |
| SCHEMBL29693652 | 0.90 | KDR (0.59) | PDGFRACSF1RPDGFRBKITRET | |
| SCHEMBL378510 | 0.90 | KDR (0.59) | PDGFRACSF1RPDGFRBKITRET | |
| SCHEMBL371670 | 0.89 | MET (0.60) | PDGFRACSF1RPDGFRBKITRET | |
| SCHEMBL26254974 | 0.88 | PDGFRA (0.50) | PDGFRACSF1RPDGFRBKITRET | |
| SCHEMBL20525758 | 0.81 | HTT (0.49) | PDGFRACSF1RPDGFRBKITRET | |
| SCHEMBL22104154 | 0.81 | PDGFRA (0.73) | PDGFRACSF1RPDGFRBKITRET | |
| SCHEMBL4413274 | 0.81 | CSF1R (0.61) | PDGFRACSF1RPDGFRBKITRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200331860-A1 | C-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2020-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200331860-A1 | C-Met Modulators and Methods of Use | FLT4, FLT1, MET | PDGFRA 63/4885CSF1R 164/4885PDGFRB 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.