Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 15/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2254964 | 0.90 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL2256841 | 0.84 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL2256375 | 0.81 | CRHR1 (0.37) | CRHR1DPP4 | |
| SCHEMBL2260164 | 0.79 | CRHR1 (0.37) | CRHR1DPP4 | |
| SCHEMBL2259379 | 0.79 | CRHR1 (0.39) | CRHR1DPP4DPP8DPP9 | |
| SCHEMBL2256733 | 0.76 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL2259373 | 0.73 | CRHR1 (0.39) | CRHR1DPP4DPP8DPP9 | |
| SCHEMBL13494254 | 0.69 | CRHR1 (0.41) | CRHR1DPP4DPP8DPP9 | |
| SCHEMBL1924250 | 0.68 | CRHR1 (0.35) | CRHR1DPP4 | |
| SCHEMBL1922595 | 0.67 | CRHR1 (0.43) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994203-B2 | Organic compounds | NOVARTIS AG (CH) | 2011-08-09 | — | — | US | disclosed |
| US-20100035874-A1 | Organic compounds | NOVARTIS AG (CH) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035874-A1 | Organic compounds | CRH, CRHR1, CRHR2 | CRHR1 2/4885DPP4 958/4885DPP8 593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.