Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.50 |
| ▸ | JUN | P05412 | 2/20 | 0.50 |
| ▸ | MERTK | Q12866 | 9/20 | 0.48 |
| ▸ | AXL | P30530 | 5/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL559027 | 1.00 | MAPK10 (0.50) | MAPK10JUNMERTKAXLTYRO3 | |
| SCHEMBL559189 | 0.87 | MAPK10 (0.51) | MAPK10JUNMERTKMAPK8MAPK9 | |
| SCHEMBL2257078 | 0.87 | MAPK10 (0.51) | MAPK10JUNMERTKMAPK8MAPK9 | |
| SCHEMBL10166034 | 0.87 | MAPK10 (0.51) | MAPK10JUNMERTKMAPK8MAPK9 | |
| SCHEMBL560142 | 0.82 | TYRO3 (0.54) | MAPK10JUNMERTKAXLTYRO3 | |
| SCHEMBL2256985 | 0.82 | TYRO3 (0.54) | MAPK10JUNMERTKAXLTYRO3 | |
| SCHEMBL558897 | 0.82 | MERTK (0.60) | MAPK10JUNMERTKAXLTYRO3 | |
| SCHEMBL2255116 | 0.82 | MERTK (0.60) | MAPK10JUNMERTKAXLTYRO3 | |
| SCHEMBL559306 | 0.80 | JUN (0.45) | MAPK10JUNMERTKAXLTYRO3 | |
| SCHEMBL559814 | 0.80 | RAB9A (0.55) | MERTKAXLTYRO3HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |