SCHEMBL22589427

SCHEMBL22589427

CCCCCCCCCOP1(=O)OC[C@H]2O[C@@H](n3ccc(N)nc3=O)C[C@@H]2O1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 3/20 0.51
▸ STING1 Q86WV6 2/20 0.42
▸ LMNA P02545 3/20 0.38
▸ PDE3A Q14432 3/20 0.38
▸ CACNA1F O60840 2/20 0.38
▸ ALB P02768 2/20 0.38
▸ MAPT P10636 2/20 0.38
▸ CACNA1D Q01668 2/20 0.38
▸ CACNA1S Q13698 2/20 0.38
▸ CACNA1C Q13936 2/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ POLG P54098 2/20 0.37
▸ POLB P06746 1/20 0.37
▸ THRB P10828 1/20 0.35
▸ MTOR P42345 1/20 0.35
▸ MDM2 Q00987 1/20 0.35
▸ NCOA1 Q15788 1/20 0.35
▸ NCOA3 Q9Y6Q9 1/20 0.35
▸ PDE4D Q08499 1/20 0.34
▸ SLC29A1 Q99808 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24625409 1.00 FGFR1 (0.51) FGFR1STING1LMNAPDE3ACACNA1F
SCHEMBL23610456 0.82 STING1 (0.42) FGFR1STING1LMNAPDE3ACACNA1F
SCHEMBL20180446 0.82 STING1 (0.42) FGFR1STING1LMNAPDE3ACACNA1F
SCHEMBL20709857 0.82 FGFR1 (0.47) FGFR1LMNAPDE3ACACNA1FALB
SCHEMBL20709883 0.82 FGFR1 (0.47) FGFR1LMNAPDE3ACACNA1FALB
SCHEMBL20709830 0.82 FGFR1 (0.47) FGFR1LMNAPDE3ACACNA1FALB
SCHEMBL20709886 0.82 FGFR1 (0.47) FGFR1LMNAPDE3ACACNA1FALB
SCHEMBL20709885 0.82 FGFR1 (0.47) FGFR1LMNAPDE3ACACNA1FALB
SCHEMBL20709829 0.82 FGFR1 (0.47) FGFR1LMNAPDE3ACACNA1FALB
SCHEMBL23105029 0.81 POLG (0.40) FGFR1STING1LMNAPDE3ACACNA1F

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220220145-A1 CYCLIC PHOSPHATE COMPOUNDS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2022-07-14 — — US disclosed
US-20220220145-A1 CYCLIC PHOSPHATE COMPOUNDS CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2022-07-14 — — US disclosed
EP-3966221-A1 CYCLIC PHOSPHATE COMPOUNDS Ligand Pharmaceuticals Incorporated (US) 2022-03-16 — — EP disclosed
CN-113939526-A Cyclic phosphate ester compound 配体药物公司 2022-01-14 — — CN disclosed
WO-2020219464-A1 CYCLIC PHOSPHATE COMPOUNDS LIGAND PHARMACEUTICALS, INC. (US) 2020-10-29 — — WO disclosed
WO-2020219464-A1 CYCLIC PHOSPHATE COMPOUNDS LIGAND PHARMACEUTICALS, INC. (US) 2020-10-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220220145-A1 CYCLIC PHOSPHATE COMPOUNDS PYGL, ALPP, PHPT1 FGFR1 907/4885STING1 1471/4885LMNA 2536/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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