Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22591172 | 0.86 | EPHX2 (0.41) | SMN1; SMN2MEN1RAB9AKMT2AHPGD | |
| SCHEMBL20289367 | 0.84 | HPGD (0.42) | SMN1; SMN2MEN1RAB9AKMT2AHPGD | |
| SCHEMBL22572280 | 0.80 | CNR1 (0.44) | MEN1KMT2AALDH1A1HDAC6 | |
| SCHEMBL20289736 | 0.80 | CNR1 (0.44) | MEN1KMT2AALDH1A1HDAC6 | |
| SCHEMBL20289694 | 0.78 | JAK1 (0.39) | SMN1; SMN2MEN1RAB9AKMT2AEPHX2 | |
| Hydrochloric Acid SCHEMBL23235884 | 0.78 | CA1 (0.42) | SMN1; SMN2MEN1RAB9AKMT2AHPGD | |
| SCHEMBL22591171 | 0.75 | EPHX2 (0.42) | SMN1; SMN2MEN1RAB9AKMT2AHPGD | |
| SCHEMBL15013037 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1RAB9AKMT2AHPGD | |
| SCHEMBL7767276 | 0.74 | MEN1 (0.63) | SMN1; SMN2MEN1RAB9AKMT2AHPGD | |
| SCHEMBL7850276 | 0.74 | RIPK1 (0.49) | SMN1; SMN2RAB9AHPGDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3763717-B1 | PYRIDO[4,3-D][1,3]OXAZIN-2-ONE COMPOUNDS AS MUTANT IDH1 AND IDH2 INHIBITORS | LILLY CO ELI (US) | 2023-03-08 | — | — | EP | disclosed |
| EP-3763717-A1 | PYRIDO[4,3-D][1,3]OXAZIN-2-ONE AND PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AS MUTANT IDH1 AND IDH2 INHIBITORS | ELI LILLY AND CO. (US) | 2021-01-13 | — | — | EP | disclosed |
| EP-3555105-B1 | 7-PHENYLETHYLAMINO-4H-PYRIMIDO[4,5-D][1,3]OXAZIN-2-ONE COMPOUNDS AS MUTANT IDH1 AND IDH2 INHIBITORS | LILLY CO ELI (US) | 2020-10-28 | — | — | EP | disclosed |