Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | NPY4R | P50391 | 4/20 | 0.39 |
| ▸ | NPY1R | P25929 | 3/20 | 0.39 |
| ▸ | NPY2R | P49146 | 3/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26445334 | 1.00 | TRPV1 (0.48) | TRPV1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL27431579 | 0.88 | SPHK1 (0.49) | SPHK1CACNA1B | |
| SCHEMBL24475446 | 0.88 | SPHK1 (0.49) | SPHK1CACNA1B | |
| SCHEMBL24086378 | 0.88 | SPHK1 (0.49) | MAPTCRHBPCRHR2SPHK1 | |
| SCHEMBL20715717 | 0.86 | TRPV1 (0.49) | TRPV1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL19466303 | 0.84 | FURIN (0.42) | TRPV1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL19466325 | 0.84 | FURIN (0.42) | TRPV1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL21167799 | 0.83 | SIRT2 (0.44) | SPHK1 | |
| SCHEMBL22593910 | 0.83 | TRPV1 (0.46) | TRPV1SMN1; SMN2GAAMAPTCRHBP | |
| SCHEMBL25100584 | 0.82 | SIRT2 (0.43) | MAPTSPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020216947-A1 | AMATOXIN ANTIBODY-DRUG CONJUGATES AND USES THEREOF | HEIDELBERG PHARMA RESEARCH GMBH (DE) | 2020-10-29 | — | — | WO | disclosed |