Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.67 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22604134 | 0.83 | GRM1 (0.70) | EGFRERBB2MEN1KMT2AGRM1 | |
| SCHEMBL11902739 | 0.83 | EGFR (0.66) | EGFRERBB2MEN1KMT2AERBB4 | |
| SCHEMBL29714896 | 0.83 | GRM1 (0.70) | EGFRERBB2MEN1KMT2AGRM1 | |
| SCHEMBL1262166 | 0.81 | EGFR (1.00) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL7976884 | 0.81 | EGFR (1.00) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL29714897 | 0.80 | EGFR (0.74) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL16994107 | 0.80 | EGFR (0.63) | EGFRERBB2ERBB4 | |
| SCHEMBL22604135 | 0.80 | EGFR (0.74) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL22590178 | 0.79 | EGFR (0.53) | EGFRERBB2MEN1KMT2AERBB4 | |
| SCHEMBL7978486 | 0.78 | EGFR (1.00) | EGFRERBB2MEN1KMT2ATNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020219906-A1 | HETEROCYCLIC INHIBITORS OF TYROSINE KINASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-10-29 | — | — | WO | disclosed |