⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25656599 | 1.00 | — | — | |
| SCHEMBL25492621 | 1.00 | — | — | |
| SCHEMBL23710650 | 1.00 | — | — | |
| SCHEMBL23710570 | 0.91 | SPHK1 (0.33) | — | |
| SCHEMBL24135559 | 0.85 | — | — | |
| SCHEMBL24091665 | 0.84 | ALDH1A1 (0.30) | — | |
| SCHEMBL21473727 | 0.83 | SPHK1 (0.30) | — | |
| SCHEMBL769556 | 0.80 | SPHK1 (0.30) | — | |
| SCHEMBL24773295 | 0.78 | SPHK1 (0.34) | — | |
| SCHEMBL20207984 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230287424-A1 | RNAi COMPOSITIONS AND METHODS OF USE THEREOF FOR DELIVERY BY INHALATION | BANK OF AMERICA, N.A. | 2023-09-14 | — | — | US | disclosed |
| US-20230183707-A1 | COMPOSITIONS AND METHODS FOR INHIBITING MARC1 GENE EXPRESSION | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-06-15 | — | — | US | disclosed |
| US-20230056569-A1 | ATAXIN3 (ATXN3) RNAI AGENT COMPOSITIONS AND METHODS OF USE THEREOF | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-02-23 | — | — | US | disclosed |
| US-20230049529-A1 | MODIFIED DOUBLE STRANDED OLIGONUCLEOTIDE | ALNYLAM PHARMACEUTICALS, INC. (US) | 2023-02-16 | — | — | US | disclosed |
| US-20230032974-A1 | SMALL RIBOSOMAL PROTEIN SUBUNIT 25 (RPS25) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF | BANK OF AMERICA, N.A. | 2023-02-02 | — | — | US | disclosed |
| US-20220127615-A1 | CORONAVIRUS IRNA COMPOSITIONS AND METHODS OF USE THEREOF | BANK OF AMERICA, N.A. | 2022-04-28 | — | — | US | disclosed |
| US-11034957-B2 | Amyloid precursor protein (APP) RNAi agent compositions and methods of use thereof | ALNYLAM PHARMACEUTICALS, INC. (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200339991-A1 | AMYLOID PRECURSOR PROTEIN (APP) RNAi AGENT COMPOSITIONS AND METHODS OF USE THEREOF | ALNYLAM PHARMACEUTICALS, INC. (US) | 2020-10-29 | — | — | US | disclosed |