Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 11/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PDE5A | O76074 | 5/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | LATS1 | O95835 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16147547 | 0.83 | KMT2A (0.46) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL459413 | 0.81 | IGF1R (0.51) | MEN1KMT2AKDM4EMAPTGAA | |
| SCHEMBL23581559 | 0.81 | ADORA3 (0.57) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL16146233 | 0.80 | CDK1 (0.49) | MEN1KMT2AHPGDLMNAMAPT | |
| SCHEMBL11015319 | 0.80 | CYP3A4 (0.46) | MEN1KMT2AKDM4EALDH1A1LMNA | |
| SCHEMBL16146716 | 0.80 | IGF1R (0.46) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16146743 | 0.80 | CDK2 (0.40) | MEN1KMT2AKDM4EALDH1A1POLB | |
| SCHEMBL5355400 | 0.80 | CHUK (0.50) | MAPT | |
| SCHEMBL30162764 | 0.80 | CHUK (0.50) | MAPT | |
| SCHEMBL3001378 | 0.80 | NFKB1 (0.46) | MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220204509-A1 | PYRIMIDO FIVE-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS MUTANT IDH2 INHIBITOR | Epitas Biosciences (shanghai) Co., Ltd. (CN) | 2022-06-30 | — | — | US | disclosed |
| US-20220204509-A1 | PYRIMIDO FIVE-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS MUTANT IDH2 INHIBITOR | Epitas Biosciences (shanghai) Co., Ltd. (CN) | 2022-06-30 | — | — | US | disclosed |
| EP-3967691-A1 | PYRIMIDO FIVE-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS MUTANT IDH2 INHIBITOR | Epitas Biosciences (Shanghai) Co., Ltd. (CN) | 2022-03-16 | — | — | EP | disclosed |
| EP-3967691-A1 | PYRIMIDO FIVE-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS MUTANT IDH2 INHIBITOR | Epitas Biosciences (Shanghai) Co., Ltd. (CN) | 2022-03-16 | — | — | EP | disclosed |
| WO-2020215998-A1 | PYRIMIDO FIVE-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS MUTANT IDH2 INHIBITOR | 上海仕谱生物科技有限公司 | 2020-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220204509-A1 | PYRIMIDO FIVE-MEMBERED HETEROCYCLIC COMPOUND AND USE THEREOF AS MUTANT IDH2 INHIBITOR | IDH2, IDH1, IDH3A | ABCG2 901/4885MEN1 1303/4885KMT2A 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.