Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.64 |
| ▸ | CDK1 | P06493 | 5/20 | 0.64 |
| ▸ | CDK2 | P24941 | 5/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.64 |
| ▸ | GSK3A | P49840 | 4/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.64 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.64 |
| ▸ | KDR | P35968 | 4/20 | 0.64 |
| ▸ | PLK4 | O00444 | 3/20 | 0.64 |
| ▸ | AURKA | O14965 | 3/20 | 0.64 |
| ▸ | FLT4 | P35916 | 3/20 | 0.64 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.64 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.64 |
| ▸ | CAMK1 | Q14012 | 2/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2260312 | 0.79 | GSK3B (1.00) | GSK3BCDK1CDK2CHEK2GSK3A | |
| SCHEMBL8790887 | 0.75 | MAPT (0.64) | GSK3BCDK1CDK2CHEK2GSK3A | |
| SCHEMBL4856192 | 0.75 | MEN1 (0.59) | GSK3BCDK1CDK2CHEK2GSK3A | |
| SCHEMBL2260262 | 0.72 | PLK4 (0.61) | GSK3BCDK1CDK2CHEK2GSK3A | |
| SCHEMBL2265197 | 0.72 | PLK4 (0.61) | GSK3BCDK1CDK2CHEK2GSK3A | |
| SCHEMBL31273494 | 0.72 | KMT2A (0.83) | GSK3BCDK1CDK2CHEK2GSK3A | |
| SCHEMBL29242097 | 0.72 | MEN1 (0.61) | GSK3BCDK1CDK2CHEK2GSK3A | |
| SCHEMBL193560 | 0.72 | MEN1 (0.61) | GSK3BCDK1CDK2CHEK2GSK3A | |
| SCHEMBL31344376 | 0.72 | MEN1 (0.61) | GSK3BCDK1CDK2CHEK2GSK3A | |
| SCHEMBL2261136 | 0.72 | PLK4 (0.60) | GSK3BCDK1CDK2CHEK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7994160-B2 | Pyridazine compounds as glycogen synthase kinase 3 inhibitors | ABBOTT GMBH & CO. KG (DE) | 2011-08-09 | — | — | US | claimed |
| US-20090325937-A1 | Pyridazine Compounds as Glycogen Synthase Kinase 3 Inhibitors | ABBOTT GMBH & CO. KG (DE) | 2009-12-31 | — | — | US | claimed |
| EP-1902055-A1 | PYRIDAZINE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2008-03-26 | — | — | EP | claimed |
| WO-2007006566-A1 | PYRIDAZINE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2007-01-18 | — | — | WO | claimed |
| US-7994160-B2 | Pyridazine compounds as glycogen synthase kinase 3 inhibitors | ABBOTT GMBH & CO. KG (DE) | 2011-08-09 | — | — | US | disclosed |
| US-20090325937-A1 | Pyridazine Compounds as Glycogen Synthase Kinase 3 Inhibitors | ABBOTT GMBH & CO. KG (DE) | 2009-12-31 | — | — | US | disclosed |
| EP-1902055-A1 | PYRIDAZINE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | Abbott GmbH & Co. KG (DE) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007006566-A1 | PYRIDAZINE COMPOUNDS AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325937-A1 | Pyridazine Compounds as Glycogen Synthase Kinase 3 Inhibitors | GSK3B, GSK3A, GYS2 | GSK3B 1/4885CDK1 7/4885CDK2 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.