Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SNCA | P37840 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29242097 | 1.00 | MEN1 (0.61) | MEN1KMT2ACAPN9CASP3SNCA | |
| SCHEMBL31344376 | 1.00 | MEN1 (0.61) | MEN1KMT2ACAPN9CASP3SNCA | |
| SCHEMBL31273494 | 0.82 | KMT2A (0.83) | MEN1KMT2ACAPN9CASP3SNCA | |
| SCHEMBL12237296 | 0.80 | CAPN9 (0.55) | MEN1KMT2ACAPN9CASP3CYP3A4 | |
| SCHEMBL29625234 | 0.79 | SNCA (0.84) | MEN1KMT2ACAPN9CASP3SNCA | |
| SCHEMBL29636440 | 0.79 | MEN1 (0.59) | MEN1KMT2ACAPN9CASP3SNCA | |
| SCHEMBL1208092 | 0.79 | SNCA (0.84) | MEN1KMT2ACAPN9CASP3SNCA | |
| SCHEMBL3031049 | 0.79 | SNCA (0.68) | MEN1KMT2ACAPN9CASP3SNCA | |
| SCHEMBL10346886 | 0.79 | MEN1 (0.59) | MEN1KMT2ACAPN9CASP3SNCA | |
| SCHEMBL11554629 | 0.79 | MEN1 (0.61) | MEN1KMT2ACAPN9CASP3SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2400976-B1 | SOFT PROTEASE INHIBITORS, AND PRO-SOFT FORMS THEREOF | TUFTS COLLEGE (US) | 2016-12-14 | — | — | EP | disclosed |
| US-8513187-B2 | Soft protease inhibitors, and pro-soft forms thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-08-20 | — | — | US | disclosed |
| US-20120178677-A1 | SOFT PROTEASE INHIBITORS, AND PRO-SOFT FORMS THEREOF | TRUSTEES OF TUFTS COLLEGE (US) | 2012-07-12 | — | — | US | disclosed |
| EP-2400976-A1 | SOFT PROTEASE INHIBITORS, AND PRO-SOFT FORMS THEREOF | Trustees Of Tufts College (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010099537-A1 | SOFT PROTEASE INHIBITORS, AND PRO-SOFT FORMS THEREOF | TRUSTEES OF TUFTS COLLEGE (US) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178677-A1 | SOFT PROTEASE INHIBITORS, AND PRO-SOFT FORMS THEREOF | DPP4, LIPE, PREP | MEN1 2451/4885KMT2A 823/4885CAPN9 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.