Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27800045 | 0.82 | NAMPT (0.55) | MDM2RAB9AKDM4EL3MBTL1BCHE | |
| SCHEMBL2640925 | 0.81 | MEN1 (0.64) | RAB9AKDM4EL3MBTL1SMN1; SMN2EPHX1 | |
| SCHEMBL19305856 | 0.80 | LMNA (0.54) | RAB9AKDM4ELMNASMN1; SMN2MEN1 | |
| SCHEMBL10666171 | 0.77 | TSHR (0.60) | MDM2KDM4EL3MBTL1BCHETAAR1 | |
| SCHEMBL334233 | 0.73 | BCHE (0.61) | MDM2RAB9AKDM4EL3MBTL1BCHE | |
| SCHEMBL7606752 | 0.72 | KDM4E (0.49) | KDM4ECA9LMNAHTTMEN1 | |
| SCHEMBL15196112 | 0.70 | MDM2 (0.67) | MDM2RAB9ATAAR1SMN1; SMN2HTT | |
| SCHEMBL8277405 | 0.70 | BCHE (0.68) | MDM2RAB9AKDM4EL3MBTL1BCHE | |
| SCHEMBL48610 | 0.70 | TSHR (0.69) | MDM2RAB9AKDM4EL3MBTL1TYK2 | |
| SCHEMBL10020286 | 0.69 | MDM2 (1.00) | MDM2RAB9AKDM4EL3MBTL1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731848-A1 | TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS TO INFLAME THE TUMOR MICROENVIRONMENT | The General Hospital Corporation (US) | 2020-11-04 | — | — | EP | disclosed |