Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10542203 | 0.87 | MAPT (0.57) | LMNAGAASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL182652 | 0.84 | MAPT (0.52) | LMNASMN1; SMN2ALDH1A1POLBMAPT | |
| SCHEMBL9699096 | 0.83 | THRA (0.60) | LMNAGAASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL9697325 | 0.83 | THRA (0.60) | LMNAGAASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL2611830 | 0.81 | ALDH1A1 (0.61) | LMNAGAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1984504 | 0.81 | ALDH1A1 (0.56) | LMNAGAASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3994737 | 0.81 | MAPT (0.64) | LMNAGAASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL30753688 | 0.81 | MAPT (0.64) | LMNAGAASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL375443 | 0.81 | ALDH1A1 (0.56) | LMNAGAASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL2234880 | 0.81 | ALDH1A1 (0.56) | LMNAGAASMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3731869-A1 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2020-11-04 | — | — | EP | disclosed |