Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.57 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29493188 | 1.00 | KDM4E (0.59) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL9735427 | 0.91 | SRD5A2 (0.69) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL5017116 | 0.89 | SRD5A2 (0.63) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL7201495 | 0.87 | SRD5A2 (0.77) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL29493184 | 0.86 | SRD5A2 (0.72) | KDM4EALDH1A1HPGDLMNAMEN1 | |
| SCHEMBL1978230 | 0.86 | SRD5A2 (0.72) | KDM4EALDH1A1HPGDLMNAMEN1 | |
| SCHEMBL630438 | 0.84 | KDM4E (0.59) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL26660706 | 0.82 | RAB9A (0.49) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL30147498 | 0.81 | ALDH1A1 (0.52) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL25724364 | 0.81 | KDM4E (0.60) | KDM4EALDH1A1HPGDRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114222747-A | PIM kinase inhibitor composition and application thereof | 斯奈普生物公司 | 2022-03-22 | — | — | CN | disclosed |
| EP-3962916-A1 | PIM KINASE INHIBITOR COMPOSITIONS AND USES THEREOF | Snap Bio, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020223306-A1 | PIM KINASE INHIBITOR COMPOSITIONS AND USES THEREOF | SNAP BIO, INC. (US) | 2020-11-05 | — | — | WO | disclosed |