Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22616951 | 1.00 | HRH3 (0.54) | HRH3ROCK1PRMT5CTSLCTSB | |
| SCHEMBL22623265 | 1.00 | HRH3 (0.54) | HRH3ROCK1PRMT5CTSLCTSB | |
| SCHEMBL22623207 | 0.84 | MAP4K4 (0.50) | HRH3ROCK1MAP4K4BTKHRH4 | |
| SCHEMBL28810474 | 0.83 | IDH1 (0.50) | HRH3ROCK1PRMT5IDH1BTK | |
| SCHEMBL28810473 | 0.83 | IDH1 (0.50) | HRH3ROCK1PRMT5IDH1BTK | |
| SCHEMBL22437600 | 0.83 | HRH3 (0.57) | HRH3ROCK1PRMT5CTSLCTSB | |
| SCHEMBL22616946 | 0.79 | CTSL (0.46) | CTSLCTSBCTSKCHRM2CHRM1 | |
| SCHEMBL22616944 | 0.78 | MAP4K4 (0.60) | HRH3MAP4K4BTKHRH4 | |
| SCHEMBL23582736 | 0.76 | EIF2AK4 (0.54) | HRH3IDH1BTK | |
| SCHEMBL23582735 | 0.76 | EIF2AK4 (0.54) | HRH3IDH1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213055-A1 | SUBSTITUTED (PIPERIDIN-1-YL)ARYL ANALOGUES FOR MODULATING AVIL ACTIVITY | UNIV VIRGINIA PATENT FOUNDATION (US) | 2022-07-07 | — | — | US | disclosed |
| US-20220213055-A1 | SUBSTITUTED (PIPERIDIN-1-YL)ARYL ANALOGUES FOR MODULATING AVIL ACTIVITY | UNIV VIRGINIA PATENT FOUNDATION (US) | 2022-07-07 | — | — | US | disclosed |
| EP-3962485-A1 | SUBSTITUTED (PIPERIDIN-1-YL)ARYL ANALOGUES FOR MODULATING AVILACTIVITY | University Of Virginia Patent Foundation (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020223715-A1 | SUBSTITUTED (PIPERIDIN-1-YL)ARYL ANALOGUES FOR MODULATING AVILACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2020-11-05 | — | — | WO | disclosed |
| WO-2020223715-A1 | SUBSTITUTED (PIPERIDIN-1-YL)ARYL ANALOGUES FOR MODULATING AVILACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2020-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213055-A1 | SUBSTITUTED (PIPERIDIN-1-YL)ARYL ANALOGUES FOR MODULATING AVIL ACTIVITY | VCL, VPS28, HDLBP | HRH3 3683/4885ROCK1 2846/4885PRMT5 1630/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.