Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22928039 | 0.82 | MAPT (0.47) | KMT2ACYP3A4CYP2C19HTTSMN1; SMN2 | |
| SCHEMBL14582133 | 0.74 | KMT2A (0.72) | KMT2ALMNAHPGDCYP3A4CYP2C9 | |
| SCHEMBL15045213 | 0.73 | KMT2A (0.71) | KMT2ALMNAHPGDHDAC1HTT | |
| SCHEMBL19512927 | 0.72 | HPGD (0.51) | KMT2ALMNAHPGDCYP3A4CYP2C9 | |
| SCHEMBL259382 | 0.71 | CA12 (0.66) | KMT2ALMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL31681311 | 0.71 | CA12 (0.66) | KMT2ALMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL3701951 | 0.71 | CA12 (0.71) | KMT2ALMNAHPGDHTTSMN1; SMN2 | |
| SCHEMBL13875341 | 0.71 | L3MBTL1 (0.67) | KMT2ALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12474917 | 0.71 | KMT2A (0.65) | KMT2ALMNAHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL1038559 | 0.71 | LMNA (0.51) | KMT2ALMNAHPGDCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3733670-A1 | TETRAHYDROPYRROLE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | Mediconns (Shanghai) Biopharmaceutical Co., Ltd (CN) | 2020-11-04 | — | — | EP | disclosed |