SCHEMBL22619367

SCHEMBL22619367

Cc1nc(-c2ccc3c(c2)C2C=CC=CC2S3)c2ccccc2n1

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 6/20 0.35
PDK1 Q15118 4/20 0.35
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
PDK2 Q15119 1/20 0.34
PDK3 Q15120 1/20 0.34
PDK4 Q16654 1/20 0.34
NUDT1 P36639 3/20 0.32
LMNA P02545 1/20 0.32
HTT P42858 1/20 0.32
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12328506 0.76
SCHEMBL15034651 0.70 ADORA2A (0.49) ADORA2APDK1KDM4EALDH1A1PDK2
SCHEMBL16542821 0.69 ADORA2A (0.47) ADORA2APDK1KDM4EALDH1A1NUDT1
SCHEMBL29986593 0.69 ADORA2A (0.47) ADORA2APDK1KDM4EALDH1A1NUDT1
SCHEMBL16542819 0.68 ADORA2A (0.57) ADORA2AKDM4EALDH1A1NUDT1LMNA
SCHEMBL29986553 0.68 ADORA2A (0.57) ADORA2AKDM4EALDH1A1NUDT1LMNA
SCHEMBL1773091 0.68 NUDT1 (0.60) ADORA2AKDM4EALDH1A1NUDT1LMNA
SCHEMBL19986162 0.68 ADORA2A (0.46) ADORA2APDK1KDM4EALDH1A1PDK2
SCHEMBL23543842 0.68 PDK1 (0.33) ADORA2APDK1KDM4EALDH1A1PDK2
SCHEMBL18235113 0.67 ADORA2A (0.49) ADORA2AKDM4EALDH1A1NUDT1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3351523-B1 COMPOUND AND ORGANIC LIGHT EMITTING DEVICE CONTAINING SAME LG CHEMICAL LTD (KR) 2020-11-04 EP disclosed