Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.46 |
| ▸ | JAK2 | O60674 | 14/20 | 0.46 |
| ▸ | JAK1 | P23458 | 13/20 | 0.45 |
| ▸ | TYK2 | P29597 | 4/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12876743 | 0.81 | JAK2 (0.53) | JAK3JAK2JAK1TYK2PRKCI | |
| SCHEMBL2359607 | 0.78 | HAVCR2 (0.48) | JAK3JAK2JAK1TYK2DAPK3 | |
| SCHEMBL29656385 | 0.77 | TTBK1 (0.48) | JAK3JAK2JAK1MAP2K1AXL | |
| SCHEMBL28798529 | 0.77 | TTBK1 (0.48) | JAK3JAK2JAK1MAP2K1AXL | |
| SCHEMBL22613348 | 0.73 | JAK3 (0.58) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL22613345 | 0.73 | JAK3 (0.58) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL20990227 | 0.73 | NUDT1 (0.65) | JAK3JAK1NUDT1 | |
| SCHEMBL24495812 | 0.71 | JAK2 (0.53) | JAK3JAK2JAK1TYK2AXL | |
| SCHEMBL1154763 | 0.68 | AXL (0.54) | JAK3JAK2JAK1TYK2AXL | |
| SCHEMBL29713778 | 0.68 | AXL (0.54) | JAK3JAK2JAK1TYK2AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020223728-A1 | SUBSTITUTED PYRROLOPYRIDINES AS JAK INHIBITORS | ACLARIS THERAPEUTICS, INC. (US) | 2020-11-05 | — | — | WO | disclosed |