Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 5/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 9/20 | 0.43 |
| ▸ | JAK3 | P52333 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28798529 | 1.00 | TTBK1 (0.48) | TTBK1TTBK2AXLNUDT1MAP2K1 | |
| SCHEMBL20990227 | 0.86 | NUDT1 (0.65) | NUDT1JAK1JAK3 | |
| SCHEMBL2632955 | 0.83 | NUDT1 (0.50) | TTBK1TTBK2AXLNUDT1MAP2K1 | |
| SCHEMBL31403755 | 0.83 | NUDT1 (0.50) | TTBK1TTBK2AXLNUDT1MAP2K1 | |
| SCHEMBL12876743 | 0.83 | JAK2 (0.53) | NUDT1JAK1JAK3JAK2 | |
| SCHEMBL2359607 | 0.83 | HAVCR2 (0.48) | AXLNUDT1MAP2K1JAK1JAK3 | |
| SCHEMBL25280494 | 0.82 | AXL (0.46) | TTBK1TTBK2AXLNUDT1MAP2K1 | |
| SCHEMBL21632535 | 0.82 | JAK3 (0.46) | TTBK1TTBK2AXLNUDT1MAP2K1 | |
| SCHEMBL31403683 | 0.82 | JAK3 (0.46) | TTBK1TTBK2AXLNUDT1MAP2K1 | |
| SCHEMBL30985188 | 0.82 | AXL (0.55) | TTBK1TTBK2AXLNUDT1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114539245-A | Pyrimidine-fused ring derivative-containing regulator, and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2022-05-27 | — | — | CN | disclosed |