SCHEMBL22625152

SCHEMBL22625152

COc1ccc(-c2cc3ccc(OC4CCC(OC(=O)C(CC(C)(C)N)C(C)(C)N)C4C(F)(F)F)cc3oc2=O)c(C(F)(F)F)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.35
NPC1 O15118 3/20 0.35
MAOB P27338 7/20 0.35
ALDH1A1 P00352 3/20 0.35
HPGD P15428 3/20 0.35
KDM4E B2RXH2 3/20 0.35
MAOA P21397 3/20 0.35
GAA P10253 2/20 0.35
RXFP1 Q9HBX9 2/20 0.35
CA12 O43570 2/20 0.35
CA2 P00918 2/20 0.35
CA9 Q16790 2/20 0.35
GLA P06280 1/20 0.35
CA3 P07451 1/20 0.35
CA4 P22748 1/20 0.35
CA6 P23280 1/20 0.35
CA7 P43166 1/20 0.35
CA14 Q9ULX7 1/20 0.35
HSD17B10 Q99714 1/20 0.35
SLC16A3 O15427 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22625040 0.86 KLK7 (0.47) RAB9ANPC1ALDH1A1HPGDKDM4E
SCHEMBL22625232 0.85 RAB9A (0.35) RAB9ANPC1MAOBALDH1A1HPGD
SCHEMBL22625163 0.83 NPC1 (0.40) RAB9ANPC1MAOBALDH1A1HPGD
SCHEMBL25849401 0.83 MAOB (0.40) RAB9ANPC1MAOBALDH1A1HPGD
SCHEMBL22625405 0.83 RAB9A (0.39) RAB9ANPC1MAOBALDH1A1HPGD
SCHEMBL22625476 0.81 RAB9A (0.35) RAB9ANPC1MAOBALDH1A1HPGD
SCHEMBL22625089 0.80 NPC1 (0.39) RAB9ANPC1MAOBALDH1A1HPGD
SCHEMBL22625233 0.80 RAB9A (0.38) RAB9ANPC1MAOBALDH1A1HPGD
SCHEMBL22625033 0.80 MAOB (0.33) MAOBHPGDKDM4EMAOASMN1; SMN2
SCHEMBL22625373 0.79 NPC1 (0.40) RAB9ANPC1MAOBALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3583102-B1 HYDROPHOBIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES MERCK PATENT GMBH (DE) 2020-11-04 EP disclosed