Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22633341 | 1.00 | CYP2D6 (0.43) | CYP2D6CYP1A2ACHECA12CA1 | |
| SCHEMBL22633358 | 0.97 | CYP2D6 (0.43) | CYP2D6CYP1A2ACHECA12CA1 | |
| SCHEMBL22633334 | 0.97 | CYP2D6 (0.43) | CYP2D6CYP1A2ACHECA12CA1 | |
| SCHEMBL14803666 | 0.94 | CYP2D6 (0.46) | CYP2D6CYP1A2ACHECA12CA1 | |
| SCHEMBL7215095 | 0.84 | ALDH1A1 (0.43) | CYP2D6CYP1A2ACHECA12CA1 | |
| SCHEMBL499873 | 0.84 | CYP2D6 (0.44) | CYP2D6CYP1A2ACHECA12CA1 | |
| SCHEMBL20129163 | 0.84 | ALDH1A1 (0.41) | CYP2D6CYP1A2ACHECA12CA1 | |
| SCHEMBL11171926 | 0.83 | ALDH1A1 (0.45) | CYP2D6CYP1A2ACHECA12CA1 | |
| SCHEMBL241884 | 0.83 | CA1 (0.52) | CYP2D6CYP1A2CA12CA1CA9 | |
| Ethylene SCHEMBL3466431 | 0.79 | CA1 (0.50) | CYP2D6CYP1A2CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12453785-B2 | Macrocyclic chelators and methods of use thereof | JANSSEN BIOTECH, INC. (US) | 2025-10-28 | — | — | US | disclosed |
| US-20230110178-A1 | Macrocyclic Chelators and Methods of Use Thereof | JANSSEN BIOTECH, INC. | 2023-04-13 | — | — | US | disclosed |
| US-11576986-B2 | Macrocyclic chelators and methods of use thereof | JANSSEN BIOTECH, INC. (US) | 2023-02-14 | — | — | US | disclosed |
| EP-3966211-A1 | MACROCYCLIC CHELATORS AND METHODS OF USE THEREOF | Janssen Biotech, Inc. (US) | 2022-03-16 | — | — | EP | disclosed |
| US-20200353105-A1 | Macrocyclic Chelators and Methods of Use Thereof | JANSSEN BIOTECH, INC. | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200353105-A1 | Macrocyclic Chelators and Methods of Use Thereof | CLASP1, CLTC, CD47 | CYP2D6 4712/4885CYP1A2 4570/4885ACHE 2059/4885 |
| US-11576986-B2 | Macrocyclic chelators and methods of use thereof | CLASP1, CLTC, CD47 | CYP2D6 4712/4885CYP1A2 4570/4885ACHE 2059/4885 |
| US-20230110178-A1 | Macrocyclic Chelators and Methods of Use Thereof | CLASP1, CLTC, CD47 | CYP2D6 4712/4885CYP1A2 4570/4885ACHE 2059/4885 |
| US-12453785-B2 | Macrocyclic chelators and methods of use thereof | CLASP1, CLTC, CD47 | CYP2D6 4712/4885CYP1A2 4570/4885ACHE 2059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.