Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 15/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16060491 | 0.96 | EPHX1 (0.65) | EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL10254622 | 0.94 | EPHX1 (0.68) | EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL16058731 | 0.92 | EPHX1 (0.53) | EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL16059507 | 0.83 | EPHX1 (0.49) | EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL11700273 | 0.80 | KEAP1 (0.51) | EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL21855156 | 0.78 | EPHX1 (0.45) | EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL26677285 | 0.77 | EPHX1 (0.87) | EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL16059493 | 0.77 | EPHX1 (0.40) | EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL16059490 | 0.77 | EPHX1 (0.40) | EPHX1KDM4EALDH1A1EPHX2 | |
| SCHEMBL16059491 | 0.77 | EPHX1 (0.40) | EPHX1KDM4EALDH1A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260125361-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC (US) | 2026-05-07 | — | — | US | disclosed |
| EP-4480953-B1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC (US) | 2026-02-04 | — | — | EP | disclosed |
| EP-4461734-B1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC (US) | 2026-02-04 | — | — | EP | disclosed |
| US-12351572-B2 | Substituted 1,2,4-triazoles as TYK2 inhibitors | ALUMIS INC. (US) | 2025-07-08 | — | — | US | disclosed |
| CN-113490664-B | TYK2 inhibitors and uses thereof | 阿鲁米斯公司 | 2025-05-16 | — | — | CN | disclosed |
| EP-4480953-A2 | TYK2 INHIBITORS AND USES THEREOF | Alumis Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| EP-4461734-A2 | TYK2 INHIBITORS AND USES THEREOF | Alumis Inc. (US) | 2024-11-13 | — | — | EP | disclosed |
| EP-3870579-B1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC (US) | 2024-10-02 | — | — | EP | disclosed |
| US-12060343-B2 | Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors | ALUMIS INC. (US) | 2024-08-13 | — | — | US | disclosed |
| US-12006306-B2 | Substituted pyridazines as TYK2 inhibitors | ALUMIS INC. (US) | 2024-06-11 | — | — | US | disclosed |
| US-20230023761-A1 | SUBSTITUTED PYRIDINES AS TYK2 INHIBITORS | ALUMIS INC. | 2023-01-26 | — | — | US | disclosed |
| US-20230021554-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. | 2023-01-26 | — | — | US | disclosed |
| US-20230023761-A1 | SUBSTITUTED PYRIDINES AS TYK2 INHIBITORS | ALUMIS INC. | 2023-01-26 | — | — | US | disclosed |
| US-20230021554-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. | 2023-01-26 | — | — | US | disclosed |
| US-20220235035-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. | 2022-07-28 | — | — | US | disclosed |
| CN-113490664-A | TYK2 inhibitors and uses thereof | 埃斯克疗法股份有限公司 | 2021-10-08 | — | — | CN | disclosed |
| US-11053219-B2 | Substituted pyridines as TYK2 inhibitors | ESKER THERAPEUTICS, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| US-11053219-B2 | Substituted pyridines as TYK2 inhibitors | ESKER THERAPEUTICS, INC. (US) | 2021-07-06 | — | — | US | disclosed |
| US-20200354338-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. | 2020-11-12 | — | — | US | disclosed |
| US-20200354338-A1 | TYK2 INHIBITORS AND USES THEREOF | ALUMIS INC. | 2020-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220235035-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK1, JAK2 | EPHX1 3175/4885KDM4E 408/4885ALDH1A1 4098/4885 |
| US-11053219-B2 | Substituted pyridines as TYK2 inhibitors | TYK2, JAK1, PDXK | EPHX1 2261/4885KDM4E 300/4885ALDH1A1 3235/4885 |
| US-20230021554-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK1, JAK2 | EPHX1 3175/4885KDM4E 408/4885ALDH1A1 4098/4885 |
| US-20230023761-A1 | SUBSTITUTED PYRIDINES AS TYK2 INHIBITORS | TYK2, JAK1, PDXK | EPHX1 2656/4885KDM4E 258/4885ALDH1A1 3600/4885 |
| US-20200354338-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK1, JAK2 | EPHX1 3175/4885KDM4E 408/4885ALDH1A1 4098/4885 |
| US-12351572-B2 | Substituted 1,2,4-triazoles as TYK2 inhibitors | TYK2, JAK1, JAK3 | EPHX1 3721/4885KDM4E 393/4885ALDH1A1 3054/4885 |
| US-12006306-B2 | Substituted pyridazines as TYK2 inhibitors | TYK2, PDXK, JAK1 | EPHX1 3429/4885KDM4E 283/4885ALDH1A1 3861/4885 |
| US-20260125361-A1 | TYK2 INHIBITORS AND USES THEREOF | TYK2, JAK1, JAK3 | EPHX1 4520/4885KDM4E 444/4885ALDH1A1 4455/4885 |
| US-12060343-B2 | Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors | TYK2, JAK1, JAK3 | EPHX1 3644/4885KDM4E 577/4885ALDH1A1 3344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.