Sugi Predict

Sugi Predict / Compounds / SCHEMBL22636744

SCHEMBL22636744

SCHEMBL22636744

O=[N+]([O-])c1cc(Br)c(F)cc1-n1cccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRIK1 P39086 3/20 0.51
▸ GRIK2 Q13002 3/20 0.51
▸ GRIK3 Q13003 3/20 0.51
▸ GRIK4 Q16099 3/20 0.51
▸ GRIK5 Q16478 3/20 0.51
▸ GRIA1 P42261 2/20 0.51
▸ GRIA2 P42262 2/20 0.51
▸ GRIA3 P42263 2/20 0.51
▸ GRIA4 P48058 2/20 0.51
▸ MAPT P10636 5/20 0.43
▸ PKM P14618 1/20 0.43
▸ MAPK1 P28482 3/20 0.42
▸ TDP1 Q9NUW8 3/20 0.40
▸ ATM Q13315 1/20 0.40
▸ LMNA P02545 2/20 0.39
▸ CTSB P07858 1/20 0.37
▸ ALDH1A1 P00352 2/20 0.35
▸ HIF1A Q16665 1/20 0.35
▸ CYP1A2 P05177 1/20 0.35
▸ CYP2D6 P10635 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20816331 0.86 GRIK1 (0.57) GRIK1GRIK2GRIK3GRIK4GRIK5
SCHEMBL30657597 0.86 GRIK1 (0.57) GRIK1GRIK2GRIK3GRIK4GRIK5
SCHEMBL22636858 0.81 GRIK1 (0.51) GRIK1GRIK2GRIK3GRIK4GRIK5
SCHEMBL29126967 0.77 GRIK1 (0.51) GRIK1GRIK2GRIK3GRIK4GRIK5
SCHEMBL30657596 0.77 GRIK1 (0.51) GRIK1GRIK2GRIK3GRIK4GRIK5
SCHEMBL30657602 0.77 GRIK1 (0.50) GRIK1GRIK2GRIK3GRIK4GRIK5
SCHEMBL27420986 0.77 GRIK1 (0.50) GRIK1GRIK2GRIK3GRIK4GRIK5
SCHEMBL29126949 0.77 GRIK1 (0.50) GRIK1GRIK2GRIK3GRIK4GRIK5
SCHEMBL23851465 0.75 MAPK1 (0.69) MAPTPKMMAPK1LMNAALDH1A1
SCHEMBL31587588 0.75 MAPK1 (0.69) MAPTPKMMAPK1LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240366595-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2024-11-07 — — US disclosed
US-12023333-B2 Phenyl-sulfamoyl.benzoyc acids as ERAP1 modulators Grey Wolf Therapeutics Limited (GB) 2024-07-02 — — US disclosed
US-20220347176-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2022-11-03 — — US disclosed
EP-3966196-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2022-03-16 — — EP disclosed
WO-2020225569-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS Grey Wolf Therapeutics Limited (GB) 2020-11-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240366595-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS CHP1, ERAP1, QSOX1 GRIK1 3306/4885GRIK2 4037/4885GRIK3 3889/4885
US-20220347176-A1 PHENYL-SULFAMOYL.BENZOYC ACIDS AS ERAP1 MODULATORS ERAP1, CHP1, QSOX1 GRIK1 3637/4885GRIK2 4227/4885GRIK3 4046/4885
US-12023333-B2 Phenyl-sulfamoyl.benzoyc acids as ERAP1 modulators ERAP1, CHP1, QSOX1 GRIK1 3264/4885GRIK2 4022/4885GRIK3 3848/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.