QSOX1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL12205530	0.55	2/20
SCHEMBL12205547	0.51	2/20
Ebselen (SCHEMBL33829)	1.00	1/20
Ebselen (SCHEMBL4406056)	1.00	1/20
SCHEMBL193047	0.79	1/20
SCHEMBL10090746	0.79	1/20
SCHEMBL4256420	0.78	1/20
SCHEMBL4309051	0.77	1/20
SCHEMBL4251117	0.76	1/20
SCHEMBL1351720	0.74	1/20
SCHEMBL1354655	0.74	1/20
SCHEMBL5885139	0.74	1/20
SCHEMBL10501092	0.74	1/20
SCHEMBL10502294	0.74	1/20
SCHEMBL13856556	0.73	1/20
SCHEMBL8292347	0.71	1/20
SCHEMBL10501773	0.70	1/20
SCHEMBL2352167	0.68	1/20
SCHEMBL5916907	0.68	1/20
SCHEMBL10501768	0.68	1/20

Clinical trials — most relevant to QSOX1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept	PHASE3	COMPLETED
Randomized Controlled Trial of Silymarin in Asthma	PHASE2/PHASE3	WITHDRAWN
Role of Antioxidants Supplementation in Chronic Pancreatitis	PHASE3	COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatment in Patients With COPD	PHASE2	COMPLETED
Effect of Gamma Tocopherol Enriched Supplementation on Response to Inhaled O3 Exposure	PHASE2	COMPLETED
Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers	PHASE2	NOT_YET_RECRUITING
Electrophilic Fatty Acid Derivatives in Asthma	PHASE1	COMPLETED
Nitrite Infusion Studies	PHASE1	COMPLETED
GSNOR Phenotyping/GSNO Challenge in Severe Asthma	EARLY_PHASE1	COMPLETED
External Nitric Oxide Measurement Through SNO Degradation	nan	ENROLLING_BY_INVITATION
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients	nan	UNKNOWN
Mechanisms of Action of Acetaminophen	nan	COMPLETED
Effects of TIVA and Inhalation Anesthesia on Oxidative Stress Factors During Hypotensive Anesthesia	nan	COMPLETED
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea	nan	RECRUITING
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Reactive Oxygen Species Following Aortic Valve Replacement	nan	COMPLETED
Treatment Strategy to Enhance Nrf2 Signaling in Older Adults	nan	COMPLETED
Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis	nan	COMPLETED
Albumin Catabolic Rate Measured by a Stable Isotope	nan	NOT_YET_RECRUITING
Characterization of the Nrf2 Response in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)	nan	RECRUITING
Role of Genetic Factors in the Development of Lung Disease	nan	RECRUITING
Effect Inhaled Nitric Oxide in Adult Liver Transplant	nan	NOT_YET_RECRUITING
Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans	nan	COMPLETED
Cleveland Heart and Metabolic Prevention Study	nan	ACTIVE_NOT_RECRUITING
Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease	nan	WITHDRAWN
Effect of Hypotensive Anesthesia on Cerebral Perfusion and Blood Antioxidant Levels and HIF 1a	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a QSOX1 binder may also engage these)

Protein	Name	Similarity
H2N4I1	—	1.000	H2N4I1 →
Q8BND5	—	1.000	Q8BND5 →
Q6IUU3	—	1.000	Q6IUU3 →
Q8JGM4	—	0.999	Q8JGM4 →
O08841	—	0.992	O08841 →
Q6AX23	—	0.983	Q6AX23 →
P17491	—	0.979	P17491 →
Q76KP1	—	0.978	Q76KP1 →
Q63259	—	0.978	Q63259 →
Q04999	—	0.978	Q04999 →
P42917	—	0.976	P42917 →
P09529	—	0.976	P09529 →
Q766D5	—	0.976	Q766D5 →
Q80WL1	—	0.975	Q80WL1 →
Q3UY90	—	0.975	Q3UY90 →
Q9Y4C5	—	0.975	Q9Y4C5 →
Q6ZMI3	—	0.975	Q6ZMI3 →
Q9H0X4	—	0.975	Q9H0X4 →
Q3V1T4	—	0.975	Q3V1T4 →
P27093	—	0.975	P27093 →
Q8BHP7	—	0.975	Q8BHP7 →
Q76HP2	—	0.975	Q76HP2 →
Q9P2V4	—	0.974	Q9P2V4 →
Q8CAL5	—	0.974	Q8CAL5 →
Q80WV3	—	0.973	Q80WV3 →
Q2KHV9	—	0.973	Q2KHV9 →
Q09200	—	0.973	Q09200 →
Q8C2S7	—	0.973	Q8C2S7 →
Q7ZV46	—	0.973	Q7ZV46 →
Q8K099	—	0.973	Q8K099 →