Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.49 |
| ▸ | LOX | P28300 | 1/20 | 0.48 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | KCNMB1 | Q16558 | 1/20 | 0.44 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.44 |
| ▸ | KCNT2 | Q6UVM3 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15495457 | 0.86 | KCNQ1 (0.47) | NOTUMKCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL16364715 | 0.78 | L3MBTL1 (0.54) | NOTUMKCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL28710638 | 0.77 | KCNT1 (0.56) | NOTUMKCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22649328 | 0.77 | KCNT1 (0.56) | NOTUMKCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637731 | 0.76 | KCNT1 (0.51) | NOTUMKCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL29463512 | 0.76 | KCNT1 (0.51) | NOTUMKCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL22637730 | 0.76 | KCNT1 (0.51) | NOTUMKCNQ1KCNH2CACNA1CSCN5A | |
| SCHEMBL15479767 | 0.76 | KCNT1 (0.58) | NOTUMKCNQ1KCNH2CACNA1CSCN5A | |
| Hydrochloric Acid SCHEMBL28705235 | 0.76 | KCNT1 (0.55) | NOTUMKCNQ1KCNH2CACNA1CSCN5A | |
| Hydrochloric Acid SCHEMBL28705236 | 0.76 | KCNT1 (0.55) | NOTUMKCNQ1KCNH2CACNA1CSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220259193-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2022-08-18 | — | — | US | disclosed |
| CN-114269340-A | KCNT1 inhibitors and methods of use | 普拉克西斯精密药物股份有限公司 | 2022-04-01 | — | — | CN | disclosed |
| EP-3962481-A1 | KCNT1 INHIBITORS AND METHODS OF USE | Praxis Precision Medicines, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020227101-A1 | KCNT1 INHIBITORS AND METHODS OF USE | PRAXIS PRECISION MEDICINES, INC. (US) | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259193-A1 | KCNT1 INHIBITORS AND METHODS OF USE | KCNT1, KCNT2, KCNQ2 | LOXL2 3485/4885NOTUM 3848/4885LOX 3282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.