Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 7/20 | 0.45 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 2/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22638081 | 0.74 | CYP1A2 (0.50) | NOS2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL22248139 | 0.71 | NOS2 (0.61) | NOS2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL28295720 | 0.71 | NOS2 (0.61) | NOS2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL116004 | 0.69 | NPC1 (0.68) | NOS2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL2952899 | 0.69 | NOS2 (1.00) | NOS2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL23038778 | 0.67 | NOS2 (0.61) | NOS2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL149707 | 0.67 | SMN1; SMN2 (0.61) | NOS2NPC1RAB9ASMN1; SMN2CYP1A2 | |
| SCHEMBL18634230 | 0.67 | NOS2 (0.61) | NOS2NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL30621933 | 0.67 | SMN1; SMN2 (0.61) | NOS2NPC1RAB9ASMN1; SMN2CYP1A2 | |
| Hydrochloric Acid SCHEMBL2956007 | 0.67 | NOS2 (0.96) | NOS2NPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11325912-B2 | Regio-selective synthesis of imidazo[1,2-a]pyrimidines | GENENTECH, INC. (US) | 2022-05-10 | — | — | US | disclosed |
| US-20200369670-A1 | REGIO-SELECTIVE SYNTHESIS OF IMIDAZO[1,2-a]PYRIMIDINES | GENENTECH, INC. (US) | 2020-11-26 | — | — | US | disclosed |
| WO-2020227576-A1 | REGIO-SELECTIVE SYNTHESIS OF IMIDAZO[1,2-A]PYRIMIDINES | GENENTECH, INC. (US) | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11325912-B2 | Regio-selective synthesis of imidazo[1,2-a]pyrimidines | CDK2, P2RY1, P2RX1 | NOS2 3928/4885NPC1 4803/4885RAB9A 3879/4885 |
| US-20200369670-A1 | REGIO-SELECTIVE SYNTHESIS OF IMIDAZO[1,2-a]PYRIMIDINES | CDK2, P2RY1, P2RX1 | NOS2 3928/4885NPC1 4803/4885RAB9A 3879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.