Isoquinoline

Isoquinoline

SCHEMBL22639031

CC(=O)OC(C)=O.c1ccc2cnccc2c1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 5/20 0.43
IMPDH2 P12268 4/20 0.43
CCNC P24863 6/20 0.41
CDK8 P49336 6/20 0.41
NOTUM Q6P988 2/20 0.40
ROCK2 O75116 1/20 0.39
KDM4E B2RXH2 2/20 0.39
MAPKAPK2 P49137 1/20 0.39
HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoquinoline SCHEMBL28990412 0.88 IMPDH2 (0.47) CYP3A4IMPDH2CCNCCDK8NOTUM
Isoquinoline SCHEMBL29093108 0.87 IMPDH2 (0.45) CYP3A4IMPDH2CCNCCDK8NOTUM
Isoquinoline SCHEMBL523706 0.86 IMPDH2 (0.50) CYP3A4IMPDH2CCNCCDK8ROCK2
Isoquinoline SCHEMBL5656668 0.85 KDM4E (0.47) CYP3A4IMPDH2CCNCCDK8ROCK2
Isoquinoline SCHEMBL8590768 0.83 SLC22A12 (0.39) CYP3A4IMPDH2NOTUMROCK2
Isoquinoline SCHEMBL11346369 0.82 IMPDH2 (0.53) CYP3A4IMPDH2CCNCCDK8ROCK2
Isoquinoline SCHEMBL27997841 0.82 KDM4E (0.48) CYP3A4IMPDH2ROCK2KDM4EMAPKAPK2
Naphthalene SCHEMBL29016507 0.82 ALDH1A1 (0.56) NOTUMKDM4EHTT
Isoquinoline SCHEMBL29093040 0.82 CCNC (0.45) CYP3A4IMPDH2CCNCCDK8NOTUM
Isoquinoline SCHEMBL28197981 0.81 IMPDH2 (0.43) CYP3A4IMPDH2CCNCCDK8NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106853966-B Utilize the method for graphene doping polyamic acid resin preparation high thermal conductivity graphite film 株洲时代新材料科技股份有限公司 2019-08-16 CN claimed
CN-106853966-A The method for preparing high heat conduction graphite film using Graphene doping polyamic acid resin 株洲时代新材料科技股份有限公司 2017-06-16 CN claimed
CN-116375016-A Method for preparing high-heat-conductivity polyimide graphite film by chemical imidization of doped graphene 苏州科丽尔化学有限公司 2023-07-04 CN disclosed
US-20220411585-A1 METHOD FOR PRODUCING POLYIMIDE FILM AND POLYIMIDE FILM MANUFACTURED THEREBY PI ADVANCED MATERIALS CO., LTD. (KR) 2022-12-29 US disclosed
WO-2020226243-A1 METHOD FOR PRODUCING POLYIMIDE FILM AND POLYIMIDE FILM PRODUCED THEREBY 피아이첨단소재 주식회사 2020-11-12 WO disclosed
CN-106853966-B Utilize the method for graphene doping polyamic acid resin preparation high thermal conductivity graphite film 株洲时代新材料科技股份有限公司 2019-08-16 CN disclosed
CN-106853966-A The method for preparing high heat conduction graphite film using Graphene doping polyamic acid resin 株洲时代新材料科技股份有限公司 2017-06-16 CN disclosed
CN-101389459-B Method for producing multilayer polyimide film KANEKA CORP 2014-12-10 CN disclosed