Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22639060 | 0.81 | CES2 (0.33) | DHODHACMSDLCKFYNDAO | |
| SCHEMBL22639072 | 0.78 | PTPN1 (0.37) | DHODHGAAMAPTALDH1A1LMNA | |
| SCHEMBL22639076 | 0.72 | CES2 (0.33) | GAAMAPTATMNPSR1ALDH1A1 | |
| SCHEMBL22639062 | 0.69 | KDM4E (0.37) | GAAALDH1A1LMNA | |
| SCHEMBL12254059 | 0.64 | KDM4E (0.44) | GAAALDH1A1LMNA | |
| SCHEMBL28498959 | 0.63 | PTGS1 (0.36) | DHODHPTGS1PTGS2 | |
| SCHEMBL7218149 | 0.63 | FFAR1 (0.55) | GAALCKFYNDAOALDH1A1 | |
| SCHEMBL22639066 | 0.63 | KDM4E (0.44) | GAAALDH1A1LMNA | |
| SCHEMBL13601583 | 0.62 | ACMSD (0.47) | DHODHMAPTACMSD | |
| SCHEMBL20924693 | 0.61 | FFAR1 (0.44) | MAPTACMSDALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020226532-A1 | SUBSTITUTED 3,4,12,12A-TETRAHYDRO-1H-[1,4]OXAZINO[3,4-C]PYRIDO[2,1-F][1,2,4]TRIAZINE-6,8-DIONE, PHARMACEUTICAL COMPOSITION, AND METHODS FOR PREPARING AND USING SAME | ИВАЩЕНКО, Александр Васильевич | 2020-11-12 | — | — | WO | disclosed |