Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.71 |
| ▸ | HPGD | P15428 | 5/20 | 0.71 |
| ▸ | TSHR | P16473 | 4/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.71 |
| ▸ | TP53 | P04637 | 2/20 | 0.71 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | PDE5A | O76074 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | VCP | P55072 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22640176 | 0.74 | KDM4E (0.56) | KDM4EHPGDTSHRHSD17B10ALOX15 | |
| SCHEMBL4812588 | 0.71 | KCNH3 (0.58) | KDM4EHPGDTSHRHSD17B10ALOX15 | |
| SCHEMBL1734655 | 0.71 | NPC1 (0.58) | KDM4EHPGDTSHRHSD17B10ALOX15 | |
| SCHEMBL5770796 | 0.70 | KDM4E (0.52) | KDM4EHPGDTSHRHSD17B10ALOX15 | |
| SCHEMBL15102175 | 0.70 | KCNH3 (0.74) | KDM4EHPGDTSHRHSD17B10ALOX15 | |
| SCHEMBL632906 | 0.70 | KCNH3 (0.68) | KDM4EHPGDMAPK1KCNH3ALDH1A1 | |
| SCHEMBL2390459 | 0.70 | KDM4E (0.48) | KDM4EHPGDTSHRHSD17B10ALOX15 | |
| SCHEMBL2571027 | 0.69 | KCNH3 (0.58) | KDM4EHPGDTSHRHSD17B10ALOX15 | |
| SCHEMBL13771616 | 0.68 | KCNH3 (0.64) | KDM4EHPGDTSHRHSD17B10ALOX15 | |
| SCHEMBL22342980 | 0.68 | ALDH1A1 (0.74) | KDM4EHPGDTSHRHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828281-B2 | Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2020-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10828281-B2 | Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect | VIM, MATR3, TP53 | KDM4E 4343/4885HPGD 550/4885TSHR 4656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.