Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.56 |
| ▸ | HTR1A | P08908 | 8/20 | 0.56 |
| ▸ | DRD2 | P14416 | 7/20 | 0.56 |
| ▸ | HTR7 | P34969 | 7/20 | 0.56 |
| ▸ | HTR6 | P50406 | 7/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3388226 | 0.79 | HTR1A (0.52) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL20557915 | 0.79 | HTR1A (0.63) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL30579382 | 0.79 | HTR1A (0.63) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL28046116 | 0.77 | HTR2A (0.64) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL13498020 | 0.77 | RAB9A (0.62) | ADORA2ARAB9AKMT2AALDH1A1HTT | |
| SCHEMBL34462989 | 0.76 | HTR1A (0.50) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL30198268 | 0.76 | PAK4 (0.53) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL12696468 | 0.76 | PAK4 (0.53) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL30579418 | 0.75 | CCNT1 (0.67) | HTR2AHTR1ADRD2HTR7HTR6 | |
| SCHEMBL7504046 | 0.75 | SMN1; SMN2 (0.52) | HTR6ADORA2AKMT2APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828281-B2 | Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2020-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10828281-B2 | Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect | VIM, MATR3, TP53 | HTR2A 3340/4885HTR1A 3508/4885DRD2 4668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.