Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22639782 | 0.79 | P2RX7 (0.59) | SMN1; SMN2KDM4ECNR2MEN1ALDH1A1 | |
| SCHEMBL8726980 | 0.74 | THRB (0.57) | SMN1; SMN2RAB9ANPC1KDM4ECYP1A2 | |
| SCHEMBL22639990 | 0.74 | KDM4E (0.53) | SMN1; SMN2RAB9ANPC1ALOX15KDM4E | |
| SCHEMBL22639969 | 0.74 | KDM4E (0.53) | SMN1; SMN2RAB9ANPC1ALOX15KDM4E | |
| SCHEMBL6360168 | 0.73 | KDM4E (0.77) | SMN1; SMN2RAB9ANPC1ALOX15KDM4E | |
| SCHEMBL30761563 | 0.73 | KMT2A (0.55) | SMN1; SMN2ALOX15KDM4EMEN1ALDH1A1 | |
| SCHEMBL21436913 | 0.73 | KMT2A (0.55) | SMN1; SMN2ALOX15KDM4EMEN1ALDH1A1 | |
| SCHEMBL10668907 | 0.73 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1KDM4ECYP1A2 | |
| SCHEMBL509136 | 0.73 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1ALOX15KDM4E | |
| SCHEMBL10671618 | 0.73 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828281-B2 | Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2020-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10828281-B2 | Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect | VIM, MATR3, TP53 | SMN1; SMN2 2515/4885RAB9A 2614/4885NPC1 475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.