Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | PDE1A | P54750 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | CCNK | O75909 | 2/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.52 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.52 |
| ▸ | MECP2 | P51608 | 1/20 | 0.51 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.51 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.51 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.51 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 14/20 | 0.51 |
| ▸ | RAB9A | P51151 | 13/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 10/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24101942 | 0.83 | PDE5A (0.51) | PDE5APDE1APDE1BPDE1CCCNK | |
| SCHEMBL24101946 | 0.83 | GAA (0.53) | PDE5APDE1APDE1BPDE1CCCNK | |
| SCHEMBL24101625 | 0.82 | CCNK (0.78) | PDE5APDE1APDE1BPDE1CCCNK | |
| SCHEMBL24101947 | 0.78 | PDE5A (0.48) | PDE5APDE1APDE1BPDE1CCCNK | |
| SCHEMBL5879523 | 0.77 | MECP2 (0.60) | MECP2KCNN1KCNN2MBD2KCNN3 | |
| SCHEMBL24102119 | 0.76 | MECP2 (0.56) | MECP2KCNN1KCNN2MBD2KCNN3 | |
| SCHEMBL525588 | 0.73 | NPC1 (0.61) | MECP2KCNN1KCNN2MBD2KCNN3 | |
| SCHEMBL1032275 | 0.73 | SMN1; SMN2 (0.53) | NPC1RAB9ALMNASMN1; SMN2TDP1 | |
| SCHEMBL5897541 | 0.72 | MECP2 (0.51) | MECP2KCNN1KCNN2MBD2KCNN3 | |
| SCHEMBL12215995 | 0.72 | RAB9A (0.65) | MECP2KCNN1KCNN2MBD2KCNN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828281-B2 | Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect | Friedrich-Alexander-Universität Erlangen-Nürnberg (DE) | 2020-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10828281-B2 | Non-hydrophobic compounds for use in treating metastasis and/or cartilage defect | VIM, MATR3, TP53 | PDE5A 4621/4885PDE1A 4847/4885PDE1B 4829/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.