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SCHEMBL22640908

SCHEMBL22640908

CC(=O)N[C@H](CO)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@H](CCC(N)=O)C(N)=O

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ SIRT5 Q9NXA8 3/20 0.49
▸ GNPAT O15228 1/20 0.49
▸ BMP1 P13497 3/20 0.48
▸ TASP1 Q9H6P5 1/20 0.47
▸ PTPN1 P18031 1/20 0.42
▸ KEAP1 Q14145 2/20 0.41
▸ HIF1A Q16665 1/20 0.41
▸ SIRT2 Q8IXJ6 1/20 0.40
▸ GRIN2D O15399 1/20 0.39
▸ GRIN3B O60391 1/20 0.39
▸ GRIN1 Q05586 1/20 0.39
▸ GRIN2A Q12879 1/20 0.39
▸ GRIN2B Q13224 1/20 0.39
▸ GRIN2C Q14957 1/20 0.39
▸ GRIN3A Q8TCU5 1/20 0.39
▸ YWHAZ P63104 1/20 0.38
▸ ACE P12821 1/20 0.38
▸ BACE1 P56817 1/20 0.37
▸ BACE2 Q9Y5Z0 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24616728 0.96 GNPAT (0.52) SIRT5GNPATBMP1TASP1PTPN1
SCHEMBL22648312 0.92 GNPAT (0.49) SIRT5GNPATBMP1TASP1PTPN1
SCHEMBL24616816 0.92 GNPAT (0.49) SIRT5GNPATBMP1TASP1PTPN1
SCHEMBL22640897 0.92 GNPAT (0.49) SIRT5GNPATBMP1TASP1PTPN1
SCHEMBL24616715 0.92 GNPAT (0.49) SIRT5GNPATBMP1TASP1PTPN1
SCHEMBL22648345 0.92 GNPAT (0.49) SIRT5GNPATBMP1TASP1PTPN1
SCHEMBL22640926 0.92 GNPAT (0.49) SIRT5GNPATBMP1TASP1PTPN1
SCHEMBL29517673 0.92 GNPAT (0.59) SIRT5GNPATBMP1TASP1
SCHEMBL17951005 0.91 SIRT5 (0.53) SIRT5GNPATBMP1TASP1PTPN1
SCHEMBL6519720 0.91 SIRT5 (0.56) SIRT5GNPATBMP1TASP1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220220155-A1 VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (ES) 2022-07-14 — — US claimed
EP-3966234-A1 VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF Consejo Superior De Investigaciones Científicas (ES) 2022-03-16 — — EP claimed
US-20220220155-A1 VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (ES) 2022-07-14 — — US disclosed
US-20220220155-A1 VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (ES) 2022-07-14 — — US disclosed
EP-3966234-A1 VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF Consejo Superior De Investigaciones Científicas (ES) 2022-03-16 — — EP disclosed
WO-2020225245-A1 VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF IPROTEOS, S.L. (ES) 2020-11-12 — — WO disclosed
EP-3736284-A1 VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF Iproteos S.L (ES) 2020-11-11 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220220155-A1 VASCULAR CHOLESTEROL INHIBITORS AND USE THEREOF LDLR, APOB, HDLBP SIRT5 2090/4885GNPAT 1017/4885BMP1 4588/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.